Insight and treatment outcome in obsessive-compulsive disorder
Insight and treatment outcome in obsessive-compulsive disorder
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DOI：
10.1053/comp.2001.27898
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发表时间：
2001-11-01
影响因子：
7.3
通讯作者：
Piggott, T
中科院分区：
文献类型：
--
作者：
Eisen, JL;Rasmussen, SA;Piggott, T
为了确定（1）强迫症（OCD）的自知力是否随着强迫症症状的改善而改善，以及（2）强迫症的自知力程度是否可以预测舍曲林的反应，从参与一项更大规模的强迫症复发多点研究的五个地点获得数据。在研究的前16周，71名患者接受舍曲林开放标签治疗，并在研究基线和终止时使用耶鲁-布朗强迫症评定量表（Y-BOCS）和评定量表（Brown评估信念量表（BABS））进行评估。基线总BABS评分与Y-BOCS评分变化无显著相关性。BABS总分变化与Y-BOCS总分变化呈显著相关。与基线时具有良好洞察力的患者（n = 57）相比，具有不良洞察力的患者（n = 14）的平均终点Y-BOCS评分无显著差异。因此，自知力随着强迫症症状严重程度的降低而改善。基线时的洞察力程度不能预测对舍曲林的反应，即，洞察力差的患者与洞察力好的患者一样可能对舍曲林有反应。Copyright（C）2001 by W.B.桑德斯公司
To determine whether (1) insight in obsessive-compulsive disorder (OCD) improves when OCD symptoms improve, and whether (2) degree of insight in OCD predicts response to sertraline, data were obtained from five sites participating in a larger multisite study of relapse in OCD. During the first 16 weeks of the study, 71 patients received open-label treatment with sertraline and were assessed using the Yale-Brown Obsessive-Compulsive Rating Scale (Y-BOCS) and a rating scale to evaluate insight, the Brown Assessment of Beliefs Scale (BABS), at study baseline and termination. Baseline total BABS score was not significantly correlated with change in Y-BOCS score. Change in BABS total score and change in Y-BOCS total score were significantly correlated. There was no significant difference in mean endpoint Y-BOCS scores for patients with poor insight (n = 14) compared to patients with good insight at baseline (n = 57). Thus, insight improved with decrease in OCD symptom severity. Degree of insight at baseline did not predict response to sertraline, i.e., patients with poor insight were just as likely to respond to sertraline as patients with good insight. Copyright (C) 2001 by W.B. Saunders Company.