Magnesium and intrauterine growth restriction
Magnesium and intrauterine growth restriction
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DOI：
10.1080/07315724.2005.10719437
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发表时间：
2005-02-01
影响因子：
3.5
通讯作者：
Leone, CR
中科院分区：
文献类型：
--
作者：
Barbosa, NOE;Okay, TS;Leone, CR
背景：宫内生长受限 (IUGR) 的存在可能会导致镁稳态失衡，这一点尚未完全阐明。目的：用术语进行描述。方法：对 70 名足月 NB 进行前瞻性研究，将其分为两组：I-30 组（不带 IUGR 的 NB）和组 II-40（不带 IUGR 的 NB）。通过经典比色终点法（Cobas-Mira，罗氏）测定血清中的 TMg 浓度，并通过 Stat Profile-M 分析仪（NOVA Biomedical）测定全血中的 iMg。 结果：我们发现，在没有 IUGR 的足月 NB 中，TMg 浓度在生命第一周内增加，并且脐带血中的 TMg 浓度低于 IUGR 的 NB（p < 0.05）。与 IUGR 的 NB 相比，未 IUGR 的 NB 在所有采样时间（即脐带血、出生后第三天和第七天）的 iMg 浓度均降低（p < 0.001）。在研究期间，iMg 浓度保持不变。我们还发现参与该研究的所有 NB 均呈现低 iMg 浓度（参考区间 0.4-0.6 mmol/L）。结论：IUGR 的存在可能会影响新生儿的镁水平，表明对围产期离子稳态的调节有影响。
Background: The presence of intrauterine growth restriction (IUGR), could potentially lead to imbalances of Mg homeostasis, which have not yet been fully clarified.Objective: To describe, in term. newborn (NB) without IUGR, ionized magnesium (iMg) and total magnesium (TMg) concentrations in umbilical cord blood, on the third and seventh days of life and to compare these values with those of term NB with IUGR.Methods: A prospective study was performed on 70 term NB divided into two groups: Group I-30 NB without IUGR and Group II-40 NB with IUGR. TMg concentrations were determined in sera by a classical colorimetric end point method (Cobas-Mira, Roche), and iMg was determined in whole blood by means of the Stat Profile-M analyzer (NOVA Biomedical).Results: We found that in term NB without IUGR, TMg concentrations increased during the first week of life and were lower than those of NB with IUGR in cord blood (p < 0.05). NB without IUGR had decreased iMg concentrations in comparison to NB with IUGR in all sampling times, i.e., cord blood, third and seventh days of life (p < 0.001). iMg concentrations remained unchanged during the study period. We also found that all NB enrolled in the study presented with low iMg concentrations (reference interval 0.4-0.6 mmol/L).Conclusion: The presence of IUGR may influence neonatal levels of magnesium, suggesting an effect on the modulation of this ion homeostasis, during the perinatal period.