β-trace protein is highly removed during haemodialysis with high-flux and super high-flux membranes
β-trace protein is highly removed during haemodialysis with high-flux and super high-flux membranes
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DOI：
10.1186/s12882-017-0489-6
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发表时间：
2017-02-20
期刊：
影响因子：
2.3
通讯作者：
Paolicchi, Aldo
中科院分区：
文献类型：
--
作者：
Donadio, Carlo;Tognotti, Danika;Paolicchi, Aldo
背景：血清 β-痕量蛋白（β TP，MW 23-29 kDa）是肾脏患者 GFR 受损的标志物。最近的论文提出根据 β TP 和其他小蛋白的血清浓度来预测维持性血液透析 (MHD) 患者的残余肾功能 (RRF)，从而避免收集尿液。关于使用具有不同通量特性的透析膜治疗的患者中 β TP 去除的数据很少。本研究的目的是评估低通量、高通量和超高通量膜血液透析对无 RRF 的 MHD 患者血清 β TP 浓度的影响。方法：对 51 名接受低通量（n = 24）、高通量（n = 17）或超高通量（n = 10）治疗的 MDH 患者在本周第一次透析前后测量血清 β TP 浓度。膜。还分析了 β 2-微球蛋白（β 2M，MW 11.8）、半胱氨酸蛋白酶抑制剂 C（Cys，MW 13.3）、尿素和肌酐的去除情况。结果：低通量膜没有去除透析结束时浓度增加的 β TP、β 2M 和 Cys。高通量膜比 β TP 更有效地去除 β 2M 和 Cys。超高通量膜去除 β TP 的效率最高：平均降低率 (RR) 53.4%，与 β 2M (59.5%) 和 Cys (62.0%) 相似。结论：总而言之，小蛋白尤其是 β TP 的血浆清除率取决于透析膜的渗透性。因此，根据血清 β TP 和其他 LMWP 预测 RRF 的公式的可靠性可能会受到透析膜不同渗透性的影响。透析膜。
Background: Serum beta-trace protein (beta TP, MW 23-29 kDa) is a marker of GFR impairment in renal patients. Recent papers propose to predict residual renal function (RRF) in maintenance haemodialysis (MHD) patients from serum concentrations of beta TP and other small proteins, avoiding the collection of urine. Few data are available on the removal of beta TP in patients treated with dialysis membranes with different flux characteristics. The aim of this study was to evaluate the effects of haemodialysis with low-flux, high-flux and super high-flux membranes on serum concentrations of beta TP in MHD patients with null RRF.Methods: Serum beta TP concentrations were measured before and after the first dialysis of the week in 51 MDH patients treated by low-flux (n = 24), high-flux ( n = 17), or super high-flux ( n = 10) membranes. The removal of beta 2- microglobulin (beta 2M, MW 11.8), cystatin C (Cys, MW 13.3), urea and creatinine was also analyzed.Results: Low-flux membranes did not remove beta TP, beta 2M and Cys whose concentration increased at the end of dialysis. High-flux membrane removed more efficiently beta 2M and Cys than beta TP. Super high-flux membrane had the highest efficiency to remove beta TP: mean reduction ratio (RR) 53.4%, similar to beta 2M (59.5%), and Cys (62.0%).Conclusions: In conclusion, the plasma clearance of small proteins and particularly of beta TP is dependent from the permeability of the dialysis membranes Therefore, the reliability of the formulas proposed to predict RRF from serum beta TP and other LMWP may be affected by the different permeability of the dialysis membranes.