Cholecystokinin modulation of [3H]noradrenaline release from superfused hypothalamic slices
Cholecystokinin modulation of [3H]noradrenaline release from superfused hypothalamic slices
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DOI：
10.1016/0304-3940(88)90131-0
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发表时间：
1988-05
影响因子：
2.5
通讯作者：
I.J.M. Beresford;M. D. Hall;C. Clark;R. Hill;J. Hughes
中科院分区：
文献类型：
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作者：
I.J.M. Beresford;M. D. Hall;C. Clark;R. Hill;J. Hughes
用硫酸化八肽胆囊收缩素（CCK-8）对钾（K+）刺激下丘脑脑片[3 H]NA释放的影响，研究了CCK-8与去甲肾上腺素（NA）的相互作用。NA和α2受体激动剂可乐定明显抑制[3 H]NA的释放，而α2受体拮抗剂育亨宾则促进[3 H]NA的释放。CCK被发现对[3 H]NA释放有显著的抑制作用，尽管抑制作用很小，但在浓度为10− 8 M时达到最大。这些结果为CCK-8抑制下丘脑NA的传递提供了证据，并为CCK-8与NA在下丘脑摄食控制中的相互作用提供了一种可能的机制。
Interactions between cholecystokinin (CCK) and noradrenaline (NA) have been studied by investigating the effect of sulphated cholecystokinin octapeptide (CCK-8) on potassium (K+)-stimulated release of [3H]NA from superfused hypothalamic slices. NA and theα2-agonist clonidine markedly inhibited [3H]NA release, while theα2-antagonist yohimbine facilitated the release process. CCK was found to give a significant, albeit small, inhibition of [3H]NA release, which was maximal at a concentration of 10−8M. These results provide evidence that CCK-8 can exert an inhibitory effect on hypothalamic NA transmission and offer one possible mechanism for the interaction of CCK and NA in the hypothalamic control of food intake.