Strain difference in the susceptibility of thymocytes to radiation-induced apoptosis: in vitro study.
Strain difference in the susceptibility of thymocytes to radiation-induced apoptosis: in vitro study.
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胸腺细胞对辐射诱导的细胞凋亡的敏感性的菌株差异：体外研究。
DOI：
10.1269/jrr.32.277
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发表时间：
1991
影响因子：
2
通讯作者：
Osamu Yagasaki
中科院分区：
文献类型：
--
作者：
N. Mori;Ryosuke Nishikawa;M. Okumoto;Kiyoshi Nishikawa;S. Imai;Nobuhiro Narita;Y. Takamori;Osamu Yagasaki
比较了STS/A胸腺细胞与BALB/cHeA胸腺细胞对辐射诱导细胞死亡的敏感性。体外暴露于12戈伊X射线后，将胸腺细胞在37 ℃下孵育8小时，然后通过0.02%赤藓红B排除法评估细胞死亡率。细胞死亡发生在2小时的孵育期，达到最大值在6小时的两个菌株。在1-24戈伊的X-照射后，检查孵育4小时时对细胞死亡的剂量效应。即使在1戈伊剂量下，两种菌株的细胞死亡也增加。BALB/cHeA中死亡细胞的数量随着剂量超过1戈伊而逐渐增加，最终在8-12戈伊的剂量范围内达到最大值（约60%），而STS/A中的最大细胞死亡约为40%。在最大细胞死亡时，菌株之间的差异是显著的（P <0.005）。两种品系之间的胸腺细胞的放射敏感性的差异不能归因于其亚群的组成的差异，因为基于CD 4和CD 8表达的流式细胞术分析显示，BALB/cHeA和STS/A的胸腺细胞亚群中没有内在差异。
The susceptibility of thymocytes from STS/A to radiation-induced cell death was compared with that of thymocytes from BALB/cHeA. After in vitro exposure to 12 Gy X-ray, thymocytes were incubated at 37 degrees C for 8 h and then cell mortality was assessed by 0.02% erythrosin B exclusion. Cell death took place from 2 h in the incubation period, reaching a maximum at 6 h for both strains. The dose-effect on cell death at 4 h of incubation was examined after 1-24 Gy of X-irradiation. An increase in cell death was detectable even at 1 Gy in both strains. The number of dead cells in BALB/cHeA gradually increased with doses of more than 1 Gy, finally to a maximum (approximately 60%) in the dose range of 8-12 Gy, whereas the maximum cell death in STS/A was approximately 40%. The difference between the strains at maximum cell death was significant (P less than 0.005). The difference in the radiosensitivity of thymocytes between the two strains could not be attributed to a difference in the composition of their subpopulations because flow cytometric analysis based on the expression of CD4 and CD8 showed no intrinsic difference in the thymocyte subpopulations of BALB/cHeA and STS/A.
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DOI：
10.1073/pnas.80.20.6361
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DUKE, RC;CHERVENAK, R;COHEN, JJ
通讯作者：
COHEN, JJ
雄激素消融后 PC-82 人类前列腺癌消退过程中的程序性细胞死亡。
影响因子：
11.2
作者：
Kyprianou,N;English,HF;Isaacs,JT
通讯作者：
Isaacs,JT
伽马射线照射的基因诱导导致淋巴细胞中的 DNA 断裂。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Sellins,KS;Cohen,JJ
通讯作者：
Cohen,JJ
IL-2 成瘾：生长因子的撤除会激活依赖性 T 细胞的自杀程序。
DOI：
--
发表时间：
1986
期刊：
Lymphokine research
影响因子：
--
作者：
Duke,RC;Cohen,JJ
通讯作者：
Cohen,JJ
影响因子：
56.9
作者：
KOURY, MJ;BONDURANT, MC
通讯作者：
BONDURANT, MC