Apocrine carcinoma in the parotid gland and in the submandibular region.
Apocrine carcinoma in the parotid gland and in the submandibular region.
复制标题
DOI：
10.1016/s1808-8694(15)31314-8
复制
发表时间：
2005-03
影响因子：
2.2
通讯作者：
中科院分区：
文献类型：
--
作者：
本文的目的是报告一例大汗腺癌，并对其诊断、治疗和预后进行讨论。与乳房外Paget病无关的顶分泌分化癌、导管型乳腺癌、Moll腺腺癌和宫颈鳞癌都是非常罕见的肿瘤。我们报告一位51岁黑人女性患上头颈部大汗腺癌的病例。两个病变累及她的左侧腮腺(第一个肿瘤和局部复发)，另一个累及她的颌下皮肤。光镜下可见：浸润性腺上皮肿瘤呈中等细胞和核多形性；肿瘤细胞呈多角形或圆形，胞核较大，胞浆嗜酸性和颗粒状。在大量囊性肿瘤细胞中可见顶端断头分泌物。此外，我们还发现粉刺样坏死或PAS阳性染色的区域(有或没有淀粉酶)。根据皮肤顶分泌癌的镜检配伍情况，我们得出结论，颌下皮肤肿瘤可能是原发肿瘤。患者接受了手术切除，经过12个月的随访期，没有发现复发或转移的证据。
The objectives of this paper are to report a case of apocrine carcinoma and the discussion of aspects related to its diagnosis, treatment, and prognosis. Carcinomas with apocrine differentiation not related to extramammary Paget's disease, ductal breast carcinoma, Moll's glands adenocarcinoma and ceruminous glands carcinoma are very uncommon tumors. We report a case of a 51-year-old black woman who developed apocrine carcinoma lesions in the head and neck region. Two lesions involved her left parotid gland (first tumor and local recurrence), and other involved her submandibular skin. The microscopic aspects were as follows: infiltrative glandular epithelial neoplasm with moderate cellular and nuclear pleomorphism; neoplasic cells with polygonal or circular shape, large nuclei and eosinophilic and granular cytoplasm. The apical decapitation secretion was viewed in a large number of intra-cystic tumor cells. Moreover, we found areas with comedo-necrosis or PAS positive staining (with or without diastase). Based on cutaneous apocrine carcinoma compatibility of the microscopic aspects, we concluded that the tumor in the submandibular skin was probably the primary neoplasm. The patient was treated by surgical excisions, and no evidence of recurrent or metastatic disease has been seen after a follow-up period of 12 months.