THE SIGNIFICANCE OF MEMBRANE-CHANGES IN THE SAFE AND EFFECTIVE USE OF THERAPEUTIC AND DIAGNOSTIC ULTRASOUND
THE SIGNIFICANCE OF MEMBRANE-CHANGES IN THE SAFE AND EFFECTIVE USE OF THERAPEUTIC AND DIAGNOSTIC ULTRASOUND
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DOI：
10.1088/0031-9155/34/11/003
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发表时间：
1989-11-01
影响因子：
3.5
通讯作者：
CRUM, LA
中科院分区：
文献类型：
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作者：
DINNO, MA;DYSON, M;CRUM, LA
细胞和组织暴露于医疗超声可导致膜变化，从而影响细胞行为。虽然这些变化中的一些可能具有治疗益处，在缓解疼痛和刺激再生和修复方面，但如果它们发生在发育过程中，其他变化可能是有害的。由于空化似乎参与产生膜变化，因此建议诊断中使用的超声水平应保持在空化阈值以下。这将根据当地的环境条件而有所不同。在确定空化阈值之前，需要更多关于体内空化发生条件的信息，特别是在体液中，如组织液或组织液、脑脊液和羊水、淋巴液和血液中。同时，为了确保超声波继续安全使用，建议在胚胎期使用时特别谨慎，此时发生早期组织发生，即在发育的前8周内，与医学研究理事会（1985）的建议一致。正是在这一时期，膜的变化在控制随后的发展中至关重要。
The exposure of cells and tissues to medical ultrasound can cause membrane changes which can affect cell behaviour. Although some of these changes could be of therapeutic benefit, in relieving pain and stimulating regeneration and repair, others could be deleterious if they were to occur during development. Since cavitation seems to be involved in producing membrane changes, it is recommended that the levels of ultrasound used diagnostically should be kept below the cavitation threshold. This will vary according to local environmental conditions. More information is needed on the conditions under which cavitation can occur in vivo, particularly in body fluids such as interstitial or tissue fluid, cerebrospinal and amniotic fluid, lymph and blood, before thresholds for cavitation can be stated with confidence. Meanwhile, in the interests of ensuring that ultrasound continues to be used safely, it is recommended that particular caution be exercised in its use during the embryonic period, when early histogenesis is occurring, that is, during the first 8 weeks of development, in line with the recommendations of the Medical Research Council (1985). It is during this period that membrane changes are of crucial importance in controlling subsequent development.