Dorsoventral lineage restriction in wing imaginal discs requires Notch
Dorsoventral lineage restriction in wing imaginal discs requires Notch
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DOI：
10.1038/46779
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发表时间：
1999-09-30
期刊：
影响因子：
64.8
通讯作者：
Blair, SS
中科院分区：
文献类型：
--
作者：
Micchelli, CA;Blair, SS
阻止细胞混合的边界的形成是一种重要的发育模式机制。果蝇发育中的成虫盘中出现的区室谱系限制是这种界限的突出例子（1）。然而，很少有人知道的细胞机制下的房室谱系限制。背腹侧（D/V）谱系限制出现在发育中的翅盘后期，需要转录因子Apterous的背侧表达，并且已经假设Apterous（ap）通过直接调节改变细胞粘附或亲和力的分子的表达来维持区室化（2）。然而，ap表达还调节背侧和腹侧隔室之间的信号传导，导致D/V边界处的高水平Notch信号传导（3-17）。在这里，我们表明，形成的Notch依赖的边界细胞IG所需的D/V谱系限制。
The formation of boundaries that prevent the intermixing of cells is an important developmental patterning mechanism. The compartmental lineage restrictions that appear in the developing imaginal discs of Drosophila are striking examples of such boundaries(1). However, little is known about the cellular mechanism underlying compartmental lineage restrictions. The dorsoventral (D/V) lineage restriction that arises late in the developing wing imaginal disc requires the dorsal expression of the transcription factor Apterous and it has been hypothesized that apterous (ap) maintains compartmentalization by directly regulating the expression of molecules that modify cell adhesion or affinity(2). However, ap expression also regulates signalling between dorsal and ventral compartments, resulting in high levels of Notch signalling at the D/V boundary(3-17). Here we show that the formation of Notch-dependent boundary cells ig required for the D/V lineage restriction.