Unimodal and Well-Defined Nanomicelles Assembled by Topology-Controlled Bicyclic Block Copolymers
Unimodal and Well-Defined Nanomicelles Assembled by Topology-Controlled Bicyclic Block Copolymers
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由拓扑控制的双环嵌段共聚物组装的单峰和明确的纳米胶束
DOI：
10.1021/acs.macromol.1c01916
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发表时间：
2022
期刊：
影响因子：
5.5
通讯作者：
Satoh Toshifumi
中科院分区：
文献类型：
--
作者：
Ree Brian J.;Satoh Yusuke;Jin Kyeong Sik;Isono Takuya;Satoh Toshifumi
本研究首次揭示了四种不同拓扑结构的双环两亲物的胶束化行为和胶束形态：bicy-BCP-A，bicy-BCP-B，bicy-BCP-C和bicy-BCP-D，它们由等摩尔分数的聚（正癸基缩水甘油醚）和聚（2-（2-（2-甲氧基乙氧基）乙氧基）乙基缩水甘油醚）嵌段组成。定量同步辐射X射线散射分析表明，所有双环两亲物自组装成单峰纳米胶束组成的核心，致密的冠，软冠结构组件。胶束还显示出与其线性对应物（l-BCP）的胶束相比显著的尺寸减小（56.7-70.7%）。通过控制双环的拓扑结构类型来区分纳米胶束的临界胶束浓度、稳定性和结构参数（形状、尺寸等）。bicy-BCP-A、-B和-C形成扁椭圆形胶束，而bicy-BCP-D和l-BCP组装成扁椭圆形胶束。发现大小按以下顺序：bicy-BCP-D <bicy-BCP-C <bicy-BCP-B <bicy-BCP-A <bicy-BCP-D <bicy-BCP-C <bicy-BCP-B <bicy-BCP-A <bicy-BCP。此外，结构稳定性按以下顺序：l-BCP <bicy-BCP-D bicy-BCP-B <bicy-BCP-C <bicy-BCP-A。这些结果表明，拓扑控制的双环嵌段共聚物可用作开发高性能功能性核壳纳米颗粒的理想平台，用于各种领域的高级应用，包括智能药物递送、生物医学成像、化妆品、高级涂层器具和分子电子学。
This study provides first insights into the micellization behavior and micellar morphologies of bicyclic amphiphiles in four different topologies:bicy-BCP-A,bicy-BCP-B,bicy-BCP-C, andbicy-BCP-D, consisting of poly(n-decyl glycidyl ether) and poly(2-(2-(2-methoxyethoxy)ethoxy)ethyl glycidyl ether) blocks in equivalent molar fractions. Quantitative synchrotron X-ray scattering analysis reveals that all bicyclic amphiphiles self-assemble into unimodal nanomicelles consisting of core, dense corona, and soft corona structural components. The micelles also demonstrate substantial size reductions (56.7–70.7%) compared to micelles of their linear counterpart (l-BCP). The critical micelle concentration, stability, and structural parameters (shape, size, and others) of nanomicelles are differentiated by controlling the bicyclic topology types.bicy-BCP-A, -B, and -C form oblate ellipsoidal micelles, whereasbicy-BCP-D andl-BCP assemble into prolate ellipsoidal micelles. The size is found to be in the following order:bicy-BCP-D <bicy-BCP-C <bicy-BCP-B <bicy-BCP-A ≪l-BCP. Furthermore, the structural stability is in the following order:l-BCP <bicy-BCP-D ≪bicy-BCP-B <bicy-BCP-C <bicy-BCP-A. These results indicate that the topology-controlled bicyclic block copolymers can be used as a desirable platform for developing high-performance functional core–shell nanoparticles for advanced applications in various fields, including smart drug delivery, biomedical imaging, cosmetics, advanced coating appliances, and molecular electronics.