Health related quality of life in different states of breast cancer
Health related quality of life in different states of breast cancer
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DOI：
10.1007/s11136-007-9202-8
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发表时间：
2007-08-01
影响因子：
3.5
通讯作者：
Rehnberg, Clas
中科院分区：
文献类型：
--
作者：
Lidgren, Mathias;Wilking, Nils;Rehnberg, Clas
目的 本研究的目的是使用基于偏好的测量来描述不同乳腺癌疾病状态下的健康相关生活质量 (HRQoL)。 材料和方法 本研究纳入了 2005 年 4 月至 5 月期间在卡罗林斯卡大学医院 Solna 乳腺癌门诊就诊的连续 361 名乳腺癌患者。使用 EQ-5D 自分类器和直接时间权衡 (TTO) 问题来估计不同乳腺癌疾病状态下的 HRQoL。 结果 原发性乳腺癌术后第一年的患者的平均 EQ-5D 指数值为 0.696（95% 置信区间 (CI)：0.634-0.747）。复发后第一年的患者平均 EQ-5D 指数值为 0.779（CI：0.700-0.849）。去年未诊断出原发性乳腺癌或复发的患者的平均 EQ-5D 指数值为 0.779（CI：0.745-0.811）。患有转移性疾病的患者报告的 HRQoL 值最低，平均 EQ-5D 指数值为 0.685（CI：0.620-0.735）。 HRQoL 下降的主要驱动因素是疼痛和不适以及焦虑和抑郁。与 EQ-5D 指数值相比，所有疾病状态的 TTO 值均较高。 结论 这项研究表明乳腺癌与 HRQoL 降低相关。这种效应对于患有转移性疾病的患者最为明显。
Objectives The aim of this study was to describe the health related quality of life (HRQoL) in different breast cancer disease states using preference-based measures.Material and Methods A total of 361 consecutive breast cancer patients attending the breast cancer outpatient clinic at Karolinska University hospital Solna for outpatient visits between April and May 2005 were included in the study. The EQ-5D self classifier and a direct Time Trade Off (TTO) question were used to estimate the HRQoL in different breast cancer disease states.Results Patients in their first year after a primary breast cancer had a mean EQ-5D index value of 0.696 (95% confidence interval (CI): 0.634-0.747)). Patients in their first year after a recurrence had a mean EQ-5D index value of 0.779 (CI: 0.700-0.849). Patients who had not had a primary breast cancer diagnosis or a recurrence during the previous year had a mean EQ-5D index value of 0.779 (CI: 0.745-0.811). Patients with metastatic disease reported the lowest HRQoL values, and had a mean EQ-5D index value of 0.685 (CI: 0.620-0.735). The main driver behind the reduction in HRQoL was pain and discomfort as well as anxiety and depression. TTO values were higher for all diseases states compared to the EQ-5D index values.Conclusion This study shows that breast cancer is associated with a reduction in HRQoL. This effect is most pronounced for patients with metastatic disease.