Sexual behaviour and HPV infections in 18 to 29 year old women in the pre-vaccine era in the Netherlands.
Sexual behaviour and HPV infections in 18 to 29 year old women in the pre-vaccine era in the Netherlands.
复制标题
DOI：
10.1371/journal.pone.0003743
复制
发表时间：
2008
期刊：
影响因子：
3.7
通讯作者：
Bekkers RL
中科院分区：
文献类型：
--
作者：
Lenselink CH;Melchers WJ;Quint WG;Hoebers AM;Hendriks JC;Massuger LF;Bekkers RL
Infection with Human Papillomavirus (HPV) is a necessary event in the multi-step process of cervical carcinogenesis. Little is known about the natural history of HPV infection among unscreened young adults. As prophylactic vaccines are being developed to prevent specifically HPV 16 and 18 infections, shifts in prevalence in the post vaccine era may be expected. This study provides a unique opportunity to gather baseline data before changes by nationwide vaccination occur. This cross-sectional study is part of a large prospective epidemiologic study performed among 2065 unscreened women aged 18 to 29 years. Women returned a self-collected cervico-vaginal specimen and filled out a questionnaire. All HPV DNA-positive samples (by SPF10 DEIA) were genotyped using the INNO-LiPA HPV genotyping assay. HPV point prevalence in this sample was 19%. Low and high risk HPV prevalence was 9.1% and 11.8%, respectively. A single HPV-type was detected in 14.9% of all women, while multiple types were found in 4.1%. HPV-types 16 (2.8%) and 18 (1.4%) were found concomitantly in only 3 women (0.1%). There was an increase in HPV prevalence till 22 years. Multivariate analysis showed that number of lifetime sexual partners was the most powerful predictor of HPV positivity, followed by type of relationship, frequency of sexual contact, age, and number of sexual partners over the past 6 months. This study shows that factors independently associated with HPV prevalence are mainly related to sexual behaviour. Combination of these results with the relative low prevalence of HPV 16 and/or 18 may be promising for expanding the future target group for catch up vaccination. Furthermore, these results provide a basis for research on possible future shifts in HPV genotype prevalence, and enable a better estimate of the effect of HPV 16-18 vaccination on cervical cancer incidence.
登录
查看更多内容
影响因子：
9.4
作者：
van Ham, MAPC;Bakkers, JMJE;Melchers, WJG
通讯作者：
Melchers, WJG
影响因子：
5.5
作者：
Dempsey, Amanda F.;Gebremariam, Achamyeleh;Manhart, Lisa
通讯作者：
Manhart, Lisa
DOI：
10.4269/ajtmh.2005.73.1.0730050
发表时间：
2005-07-01
影响因子：
3.3
作者：
Tábora, N;Zelaya, A;Ferrera, A
通讯作者：
Ferrera, A
影响因子：
3.8
作者：
Wiley, Dorothy J.;Wiesmeier, Edward;Rao, Jian Yu
通讯作者：
Rao, Jian Yu
影响因子：
6.4
作者：
Fenton, KA;Mercer, CH;Wellings, K
通讯作者：
Wellings, K