Galectin-3 as a Potential Target to Prevent Cancer Metastasis.
Galectin-3 as a Potential Target to Prevent Cancer Metastasis.
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DOI：
10.4137/cmo.s29462
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
AlSadek DM
中科院分区：
文献类型：
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作者：
Ahmed H;AlSadek DM
Interactions between two cells or between cell and extracellular matrix mediated by protein–carbohydrate interactions play pivotal roles in modulating various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Galectin-3, a member of the β-galactoside-binding lectin family, is involved in fibrosis as well as cancer progression and metastasis, but the detailed mechanisms of its functions remain elusive. This review discusses its structure, carbohydrate-binding properties, and involvement in various aspects of tumorigenesis and some potential carbohydrate ligands that are currently investigated to block galectin-3 activity.
