Papillary squamous cell carcinoma of the uterine cervix: a report of two cases with human papillomavirus 16 DNA
Papillary squamous cell carcinoma of the uterine cervix: a report of two cases with human papillomavirus 16 DNA
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DOI：
10.1034/j.1600-0412.2002.810217.x
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发表时间：
2002-02-01
影响因子：
4.3
通讯作者：
Fujimoto, S
中科院分区：
文献类型：
--
作者：
Fujimoto, T;Sakuragi, N;Fujimoto, S
子宫颈乳头状鳞状细胞癌（PSCC）最初由Randell等人于1986年描述为鳞状细胞癌（SCC）的一个独特实体（1）。在组织学上，PSCC的特征是片状的非典型基底细胞样细胞，通常不角化，显示中度至重度的核增生，并由纤维血管核心支持。乳头状鳞状细胞癌似乎有晚期复发的倾向。HPV和鳞状细胞癌之间的关系已经很好地建立，HPV 16，18，31和35，所谓的高危型HPV类型，与SCC密切相关。然而，PSCC是否与HPV感染相关仍不清楚（2）。在这份报告中，我们提出了两例与HPV 16 DNA相关的PSCC，并讨论其组织病理学特征。
Papillary squamous cell carcinoma (PSCC) of the uterine cervix was originally described as a distinctive entity of squamous cell carcinoma (SCC) by Randell et al. in 1986 (1). Histologically, PSCC is characterized by sheets of atypical basaloid cells, often non-keratinizing, showing moderate to severe nuclear atypia and supported by fibrovascular cores. Papillary squamous cell carcinoma seems to have a propensity for late recurrences. The relation between HPV and squamous cell carcinoma has been well established, and HPV16, 18, 31, and 35, so-called high-risk HPV types, are strongly associated with SCC. It remains unclear, however, whether PSCC is associated with HPV infection (2). In this report we present two cases of PSCC associated with HPV 16 DNA and discuss its histopathological features.