Mechanisms of angiotensin-converting enzyme inhibitor induced thrombolysis in Wistar rats
Mechanisms of angiotensin-converting enzyme inhibitor induced thrombolysis in Wistar rats
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DOI：
10.1016/j.thromres.2003.08.005
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发表时间：
2003-06-15
影响因子：
7.5
通讯作者：
Marcinkiewicz, E
中科院分区：
文献类型：
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作者：
Gryglewski, RJ;Swies, J;Marcinkiewicz, E
我们的体内溶栓试验包括记录富含血小板的血栓粘附在胶原条上的重量，该胶原条在麻醉Wistar大鼠的脑外循环中用动脉血灌注。静脉注射血管紧张素转换酶抑制剂（ACE-I）3 - 30 μ g/kg（-1）（captopril < perinclopril < quinapril）后立即发生血栓溶解。溶栓反应持续3小时，血栓重量最大减少75%。用COX-1和考克斯-3抑制剂（低剂量阿司匹林1 mg/kg，SC 560和对乙酰氨基酚0.3-3 mg/kg）预处理略微增强ACE-1的溶栓作用，而考克斯-2抑制剂（尼美舒利和昔布类药物剂量为
Our in vivo assay for thrombolysis consisted of recording the weight of platelet-rich thrombi adhering to a collagen strip that was superfused with arterial blood in extracorporal circulation of anaesthetised Wistar rats. Immediate thrombolysis occurred in response to intravenously administrated angiotensin-converting enzyme inhibitor (ACE-I) at non-hypotensive doses of 3 - 30 mug kg(-1) (captopril < perinclopril < quinapril). The thrombolytic response lasted up to 3 h with maximum reduction of the weight of thrombus by 75%. Pretreatment with COX-I and COX-3 inhibitors (aspirin at a low dose of 1 mg kg(-1), SC 560 and acetaminophen, 0.3-3 mg kg(-1)) slightly augmented thrombolysis by ACE-I, while COX-2 inhibitors (nimesulide and coxibs at doses