Elevated plasma brain natriuretic peptide level in cardiac sarcoidosis patients with preserved ejection fraction
Elevated plasma brain natriuretic peptide level in cardiac sarcoidosis patients with preserved ejection fraction
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DOI：
10.1159/000095518
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发表时间：
2007-01-01
期刊：
影响因子：
1.9
通讯作者：
Mochizuki, Seibu
中科院分区：
文献类型：
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作者：
Date, Taro;Shinozaki, Toshihide;Mochizuki, Seibu
我们试图检查心脏结节病患者的血浆脑利钠肽(BNP)水平是否在射血分数保留的情况下升高。分析超声心动图上无心脏受累的肺结节病(n=13)和射血分数(>；55%)保留的心脏结节病(n=8)的资料。心脏结节病患者血浆脑钠素水平显著高于肺结节病患者(101.5±65.1vs.15.6+/-10.5pg/ml，p<；0.001)，但两组患者的左心室射血分数无显著差异。因此，血浆BNP水平被认为是一种有用的非侵入性生物标志物，可用于识别射血分数保留的结节病患者可能的心脏损害。
We sought to examine whether the plasma brain natriuretic peptide (BNP) levels are elevated in the cardiac sarcoidosis patients even with a preserved ejection fraction. The data from the patients with either pulmonary sarcoidosis without any evidence of cardiac involvement (n = 13) or cardiac sarcoidosis (n = 8) with a preserved ejection fraction (> 55%) on echocardiography were analyzed. The median plasma BNP levels were significantly higher in the patients with cardiac sarcoidosis than in those with pulmonary sarcoidosis (101.5 +/- 65.1 vs. 15.6 +/- 10.5 pg/ml, p < 0.001), although there was no significant difference in left ventricular ejection fraction between the two populations. The plasma BNP level is thus considered to be a useful non-invasive biomarker for identifying a possible cardiac involvement in the sarcoidosis patients with a preserved ejection fraction.