Stressful life events, chronic difficulties, and the symptoms of clinical depression.
Stressful life events, chronic difficulties, and the symptoms of clinical depression.
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DOI：
10.1097/nmd.0b013e318199f77b
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发表时间：
2009-03
期刊：
影响因子：
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通讯作者：
Gotlib IH
中科院分区：
文献类型：
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作者：
Muscatell KA;Slavich GM;Monroe SM;Gotlib IH
重大生活事件和慢性困难已被发现与抑郁症的发病有关。然而，鲜为人知的是，如何暴露于这种压力源是与这种疾病的临床表现。我们通过对100名诊断为重度抑郁症的成年人进行基于访谈的生活压力测量、贝克抑郁量表和功能量表全球评估来解决这个问题。经历过严重生活事件的参与者表现出更高的抑郁症严重程度的整体水平，认可更多的抑郁症的认知和躯体症状，并且比没有严重生活事件的参与者表现出更低的功能水平。相比之下，暴露于发病前的严重困难与参与者的抑郁严重程度，认知和躯体症状或整体功能水平无关。这些发现强调了急性应激与慢性应激相比在影响抑郁症的这些关键临床特征方面的潜在更大重要性。
Major life events and chronic difficulties have been found to be associated with the onset of depression. Little is known, however, about how exposure to such stressors is related to the clinical presentation of this disorder. We addressed this issue by administering an interview-based measure of life stress, the Beck Depression Inventory, and the Global Assessment of Functioning scale to 100 adults diagnosed with major depressive disorder. Participants who experienced a preonset severe life event exhibited greater overall levels of depression severity, endorsed more cognitive and somatic symptoms of depression, and functioned at lower levels than did their counterparts without preonset severe life events. In contrast, exposure to a preonset severe difficulty was unrelated to participants’ severity of depression, cognitive and somatic symptoms, or level of global functioning. These findings highlight the potentially greater importance of acute stress compared with chronic stress for influencing these key clinical features of depression.