Is routine follow-up useful after combined-modality therapy for advanced head and neck cancer?
Is routine follow-up useful after combined-modality therapy for advanced head and neck cancer?
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DOI：
10.1001/archotol.125.4.379
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发表时间：
1999-04-01
影响因子：
--
通讯作者：
Poulsen, MG
中科院分区：
文献类型：
--
作者：
Cooney, TR;Poulsen, MG
设计：回顾队列研究，对所有患者进行为期5年的随访。患者：从1970年1月1日至1990年12月31日，对3002例晚期(III或IV期)口腔、口咽、下咽和喉部鳞状细胞癌患者进行手术和术后放射治疗。主要观察指标：指标性肿瘤复发或发生第二原发头颈部肿瘤后的生存率。结果：总体5年生存率为56%。119名患者复发，49名患者尝试了抢救治疗。只有2例患者在复发后存活至5年。结论：在晚期头颈部鳞状细胞癌患者中，常规随访对评估治疗结果和情感支持的重要性大于对提高患者生存的益处。
Objective: To evaluate the usefulness of routine follow-up in a selected group of patients with head and neck cancer.Design: Retrospective cohort study with follow-up of 5 years for all patients.Patients: Three hundred two patients with advanced (stage III or IV) squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx were treated with curative intent with surgery and postoperative radiation therapy between January 1, 1970, and December 31, 1990.Main Outcome Measure: Survival after recurrence of the index tumor or the development of a second head and neck primary tumor.Results: Overall actuarial 5-year survival was 56%. Relapse occurred in 119 patients, and salvage therapy was attempted in 49 patients. Only 2 patients survived to 5 years after relapse.Conclusion: In patients with advanced head and neck squamous cell carcinoma, routine follow-up is more important for evaluation of treatment results and emotional support than of benefit in improving patient survival.