Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-beta.

Inhibition of Nb2 T-lymphoma cell growth by transforming growth factor-beta.
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通过转化生长因子-β 抑制 Nb2 T 淋巴瘤细胞生长。

DOI:
10.1042/bj2530295
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发表时间:
1988
期刊:
The Biochemical journal
影响因子:
--
通讯作者:
Hughes,JP
Hughes,JP
中科院分区:
--
文献类型:
--
作者:
Rayhel,EJ;Prentice,DA;Tabor,PS;Flurkey,WH;Geib,RW;Laherty,RF;Schnitzer,SB;Chen,R;Hughes,JP

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Transforming growth factor-beta (TGF-beta) inhibits proliferation of Nb2 cells, a rat T lymphoma, in response to lactogens and interleukin-2. Prostaglandins may play an important role in the pathway through which TGF-beta exerts its inhibitory actions, because prostaglandin E2 also inhibits proliferation of Nb2 cells, and indomethacin, an inhibitor of prostaglandin synthesis, reverses the inhibitory effects of TGF-beta on Nb2 cell proliferation.