The impact of medical cannabis consumption on the oral flora and saliva.
The impact of medical cannabis consumption on the oral flora and saliva.
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DOI：
10.1371/journal.pone.0247044
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Jabbour A
中科院分区：
文献类型：
--
作者：
Habib G;Steinberg D;Jabbour A
评估医用大麻消费对口腔菌群和唾液的影响。拿撒勒拿撒勒医院风湿病诊所的一项临床前瞻性研究，连续招募了批准使用医用大麻的患者，评估他们在医用大麻治疗之前和治疗期间的唾液流量、pH 值以及变形链球菌和乳酸菌的微生物负荷。最近获得医用大麻治疗许可的患者在开始消费医用大麻之前（第 0 周）被招募，1 周和 4 周后，患者提供 5 分钟的唾液样本，测量其体积和 pH 值，并在特殊的微生物试剂盒上进行培养，评估变形链球菌和乳杆菌的生长。在 16 名入组患者中，14 名是女性，患有纤维肌痛。患者的平均年龄为52.8±12.9岁。第 0 周、第 1 周和第 4 周的平均唾液流量分别为 5.38±3.36 毫升/5 分钟、6 (p = 0.769) 和 5.45 (p = 0.391)，唾液 pH 值也分别为 6.28、5.94 (p = 0.51) 和 5.5 (p = 0.07)。第 0、1 和 4 周的平均变形链球菌生长评分分别为 1.8±0.75、1.6±0.83 (p = 0.234) 和 2.4±0.84 (p = 0.058)。第 0、1 和 4 周的平均乳酸菌生长评分分别为 2.59±0.88、3.1±0.69 (p = 0.033) 和 3.3±0.67 (p = 0.025)。这项研究的结果表明，食用医用大麻对唾液量或 pH 值没有显着影响，但可能与唾液中变形链球菌和乳酸杆菌等口腔微生物水平的变化有关。
To evaluate the effect of medical cannabis consumption on oral flora and saliva. A clinical prospective study, at the rheumatology clinic of the Nazareth Hospital in Nazareth, recruiting consecutively patients approved for medical cannabis, evaluating their saliva flow, pH and microbial load of Streptococcus mutans and Lactobacillus, prior to and under medical cannabis treatment. Patients recently licensed for medical cannabis treatment, were recruited just prior to starting medical cannabis consumption (week 0), 1 and 4 weeks later, patients provided 5-minute time saliva samples, which were measured for their volume and pH, and cultured on a special microbial kit, evaluating the growth of Streptococcus mutans and Lactobacillus. Out of 16 patients enrolled, 14 were female and had fibromyalgia. The mean age of the patients was 52.8±12.9 years. The mean saliva flow at week 0, week 1 and week 4 were 5.38±3.36 ml/5-minutes, 6 (p = 0.769) and 5.45 (p = 0.391), respectively, and for saliva pH were 6.28, 5.94 (p = 0.51) and 5.5 (p = 0.07) respectively also. The mean Streptococcus mutans growth score at weeks 0, 1 and 4 was1.8±0.75, 1.6±0.83 (p = 0.234), and 2.4±0.84 (p = 0.058), respectively. The mean Lactobacilli growth score at weeks 0, 1 and 4 was 2.59±0.88, 3.1±0.69 (p = 0.033) and 3.3±0.67 (p = 0.025), respectively. The results of this study show that medical cannabis consumption has no significant effect on saliva volume or pH, but it may be associated with changes in salivary levels of oral microbes such as Streptococcus mutans and Lactobacilli.