Optimization and standardization of lung densitometry in the assessment of pulmonary emphysema
Optimization and standardization of lung densitometry in the assessment of pulmonary emphysema
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DOI：
10.1097/00004424-200411000-00006
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发表时间：
2004-11-01
影响因子：
6.7
通讯作者：
Stolk, J
中科院分区：
文献类型：
--
作者：
Stoel, BC;Stolk, J
目前，用于评估肺气肿的肺密度测定法已根据病理学、肺功能和健康状况得到充分验证，因此正应用于药理学试验。然而，其应用于肺气肿的早期检测尚未在日常临床实践中引入。其主要原因是它尚未被视为一种完全优化和标准化的技术。在这项工作中，概述了在这方面发挥重要作用的不同标准化方面的现状，即图像采集，密度参数的选择和图像处理。为了解决这些问题，已经从文献和先前研究的原始数据中寻求解决方案。肺密度测定的标准化和优化已经达到了比迄今为止报道的更先进的阶段。如果能够获得正常值，则该技术在临床实践中将是可行的。因此，可以在更短的时间内实现其他密度相关肺部疾病检测和评估的标准化。
Currently, lung densitometry for the assessment of pulmonary emphysema has been fully validated against pathology, pulmonary function, and health status, and it is therefore being applied in pharmacotherapeutic trials. Nevertheless, its application for the early detection of emphysema has not yet been introduced in daily clinical practice. The main reason for this is the fact that it is not yet regarded a fully optimized and standardized technique. In this work, an overview is given on the current status of different standardization aspects that play an important role in this, ie, image acquisition, choice of densitometric parameter and image processing. To address these issues, solutions have been sought from the literature and from original data from previous studies. Standardization and optimization of lung densitometry has reached a more advanced stage than has been reported so far. If normal values will become available, this technique will be feasible for clinical practice. As a result, standardization for the detection and assessment of other density-related lung diseases can be achieved in a shorter period of time.