Oral bacterial flora and oral cancer: The possible link?
Oral bacterial flora and oral cancer: The possible link?
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DOI：
10.4103/jomfp.jomfp_89_16
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Sridharan G
中科院分区：
文献类型：
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作者：
Gaonkar PP;Patankar SR;Tripathi N;Sridharan G
口腔癌具有多因素病因学，长期以来烟草和酒精被认为是主要的危险因素。此外，槟榔、饮食因素和口腔卫生不良也被发现在口腔癌的病因中起作用。过去的研究已经发现了大量关于外源性细菌与癌症相关的信息。然而，我们对口腔细菌和口腔癌之间的联系的确切认识仍然不足。在本文中，我们假设口腔细菌植物群在口腔癌中的因果作用，尽管是间接的。我们认为，正常的细菌植物群与已经确定的危险因素，如饮酒，可能在癌症的发展中发挥作用。对这一课题的继续探索可能有助于更好地了解口腔癌的发病机制，从而有助于适当的治疗和更好的预后。
Oral cancer exhibits multifactorial etiology with tobacco and alcohol long been implicated as the primary risk factors. In addition, betel nut, dietary factors and poor oral hygiene have also been found to have a role in the etiology of oral cancer. Past research has uncovered a great deal of information regarding the association of exogenous bacteria with cancer. However, our definitive knowledge of the oral commensal bacteria and oral cancer link remains inadequate. In the present article, we hypothesize a causal role for oral bacterial flora in oral cancer although an indirect one. We propose that the normal bacterial flora in conjunction with the already established risk factors such as alcohol consumption may play a role in cancer development. The continued exploration of this topic may aid in better understanding of the pathogenesis of oral cancer thereby helping in appropriate treatment and better prognosis.