Methicillin‐resistant Staphylococcus aureus bacteremia in children
Methicillin‐resistant Staphylococcus aureus bacteremia in children
复制标题
儿童耐甲氧西林金黄色葡萄球菌菌血症
DOI：
10.1097/00006454-198601000-00012
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
L. Rajagopalan
中科院分区：
文献类型：
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作者：
G. Storch;L. Rajagopalan
我们回顾了20例耐甲氧西林金黄色葡萄球菌（MRSA）引起的菌血症患者和49例甲氧西林敏感的金黄色葡萄球菌（MRSA）引起的菌血症患者。金黄色葡萄球菌（MSSA）菌血症发生在39个月期间。16例MRSA菌群具有临床意义，42例MSSA菌群具有临床意义。MRSA菌血症几乎总是院内感染，主要发生在非常年轻的患者中，这些患者通常早产并受到基础疾病的严重影响。相比之下，MSSA菌血症患者通常是年龄较大的儿童，他们没有基础疾病，并在社区获得了菌血症疾病。7例院内MSSA菌血症患者的特征与MRSA菌血症患者相似。具有临床意义的菌血症患者的死亡率MRSA为50%，MSSA为2%。万古霉素治疗MRSA菌血症是有效的，只要早期开始。在MRSA流行的医院，可能有必要在高危患者的医院内菌血症的初始治疗中使用万古霉素，直到可以确定血流病原体的身份和抗菌药物敏感性。
We reviewed the records of 20 patients with bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) and 49 patients with methicillin-susceptible S. aureus (MSSA) bacteremia occurring during a 39-month period. Sixteen of the MRSA bacteremias were clinically significant, as were 42 of the MSSA bacteremias. MRSA bacteremia was almost always nosocomial and occurred mainly in very young patients who were often prematurely born and severely compromised by underlying diseases. In contrast patients with MSSA bacteremia were frequently older children who had no underlying disease and acquired their bacteremic illness in the community. The seven patients with nosocomial MSSA bacteremia had characteristics similar to those of the patients with MRSA bacteremia. Fatality rates for patients with clinically significant bacteremia were 50% for MRSA and 2% for MSSA. Treatment of MRSA bacteremia with vancomycin was effective, provided it was begun early. At hospitals with endemic MRSA it may be necessary to use vacomycin in the initial treatment of nosocomial bacteremia in high risk patients until the identity and antimicrobial susceptibility of the bloodstream pathogen can be determined.