Dementia in Down's syndrome: an MRI comparison with Alzheimer's disease in the general population.
Dementia in Down's syndrome: an MRI comparison with Alzheimer's disease in the general population.
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DOI：
10.1186/1866-1955-5-19
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发表时间：
2013-08-20
影响因子：
4.9
通讯作者：
Murphy DG
中科院分区：
文献类型：
--
作者：
Mullins D;Daly E;Simmons A;Beacher F;Foy CM;Lovestone S;Hallahan B;Murphy KC;Murphy DG
唐氏综合症（DS）是智力障碍最常见的遗传原因。与普通人群相比，DS 患者患阿尔茨海默病 (AD) 的风险更高。 AD 的神经影像学研究主要集中在内侧颞叶结构；然而，据我们所知，尚无对 DS 痴呆症患者与普通人群 AD 患者的解剖结构进行比较的体内病例对照研究。因此，我们将 DS 和痴呆症 (DS+) 患者与普通人群中 AD 患者的体内大脑解剖结构进行了比较。我们使用 192 名成年人的 MRI 技术，比较了患有或不患有痴呆症的 DS 受试者（DS+、DS-）的全脑物质、侧脑室、颞叶和海马体的体积，以及彼此之间以及与三个非 DS 组的体积。其中包括一组患有 AD 的个体和两组对照组（每组的年龄与各自的 DS 和一般人群 AD 队列相匹配）。与非痴呆受试者相比，AD 和 DS+ 受试者的整个大脑、海马体和颞叶的体积显着减少，侧脑室的体积显着增加。与 AD 患者相比，DS+ 患者的颞叶体积减少幅度较小。 DS+和AD受试者的相同大脑区域的体积显着减少。我们发现初步证据表明，DS 个体可能比其他人对组织损失更敏感，并且“认知储备”较少。
Down’s syndrome (DS) is the most common genetic cause of intellectual disability. People with DS are at an increased risk of Alzheimer’s disease (AD) compared to the general population. Neuroimaging studies of AD have focused on medial temporal structures; however, to our knowledge, no in vivo case–control study exists comparing the anatomy of dementia in DS to people with AD in the general population. We therefore compared the in vivo brain anatomy of people with DS and dementia (DS+) to those with AD in the general population. Using MRI in 192 adults, we compared the volume of whole brain matter, lateral ventricles, temporal lobes and hippocampus in DS subjects with and without dementia (DS+, DS-), to each other and to three non-DS groups. These included one group of individuals with AD and two groups of controls (each age-matched for their respective DS and general population AD cohorts). AD and DS+ subjects showed significant reductions in the volume of the whole brain, hippocampus and temporal lobes and a significant elevation in the volume of the lateral ventricle, compared to their non-demented counterparts. People with DS+ had a smaller reduction in temporal lobe volume compared to individuals with AD. DS+ and AD subjects have a significant reduction in volume of the same brain regions. We found preliminary evidence that DS individuals may be more sensitive to tissue loss than others and have less ‘cognitive reserve’.