An ensemble classifier for eukaryotic protein subcellular location prediction using gene ontology categories and amino acid hydrophobicity.
An ensemble classifier for eukaryotic protein subcellular location prediction using gene ontology categories and amino acid hydrophobicity.
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使用基因本体类别和氨基酸疏水性预测真核蛋白质亚细胞位置的集成分类器
DOI:
10.1371/journal.pone.0031057
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发表时间:
2012
期刊:
影响因子:
3.7
通讯作者:
Zhou Y
中科院分区:
文献类型:
--
作者:
Li L;Zhang Y;Zou L;Li C;Yu B;Zheng X;Zhou Y
With the rapid increase of protein sequences in the post-genomic age, it is challenging to develop accurate and automated methods for reliably and quickly predicting their subcellular localizations. Till now, many efforts have been tried, but most of which used only a single algorithm. In this paper, we proposed an ensemble classifier of KNN (k-nearest neighbor) and SVM (support vector machine) algorithms to predict the subcellular localization of eukaryotic proteins based on a voting system. The overall prediction accuracies by the one-versus-one strategy are 78.17%, 89.94% and 75.55% for three benchmark datasets of eukaryotic proteins. The improved prediction accuracies reveal that GO annotations and hydrophobicity of amino acids help to predict subcellular locations of eukaryotic proteins.
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