Regulation of epigenetic traits of the glutathione S-transferase P1 gene: from detoxification toward cancer prevention and diagnosis.
Regulation of epigenetic traits of the glutathione S-transferase P1 gene: from detoxification toward cancer prevention and diagnosis.
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DOI：
10.3389/fphar.2014.00170
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发表时间：
2014
影响因子：
5.6
通讯作者：
Diederich M
中科院分区：
文献类型：
--
作者：
Schnekenburger M;Karius T;Diederich M
谷胱甘肽S-转移酶（GST）是II相药物解毒酶，其通过催化谷胱甘肽与多种外源性和内源性亲电子底物的缀合而在维持细胞完整性和保护DNA免受损伤方面发挥重要作用。谷胱甘肽S-转移酶P1（GSTP 1）是编码π-类GST的基因，在多种癌症亚型（包括前列腺癌、乳腺癌、肝癌和血癌）中经常被获得性体细胞CpG岛启动子超甲基化灭活。表观遗传学介导的GSTP 1沉默通过降低其“看守”基因功能而与增强的癌症易感性相关，其倾向于促进肿瘤转化，允许细胞获得额外的改变。因此，这种表观遗传学改变现在被认为是癌症生物标志物，但也可能在多步骤癌症发展中发挥驱动作用，特别是在前列腺癌发展中有充分的记录。本综述讨论了影响GST P1的表观遗传学改变在癌症医学中的应用，这些表观遗传学改变单独使用或与其他生物标志物结合使用，用于癌症检测和诊断，以及用于未来有针对性的预防和治疗干预，包括通过膳食剂。
Glutathione S-transferases (GSTs) are phase II drug detoxifying enzymes that play an essential role in the maintenance of cell integrity and protection against DNA damage by catalyzing the conjugation of glutathione to a wide variety of exo- and endogenous electrophilic substrates. Glutathione S-transferase P1 (GSTP1), the gene encoding the pi-class GST, is frequently inactivated by acquired somatic CpG island promoter hypermethylation in multiple cancer subtypes including prostate, breast, liver, and blood cancers. Epigenetically mediated GSTP1 silencing is associated with enhanced cancer susceptibility by decreasing its “caretaker” gene function, which tends to promote neoplastic transformation allowing cells to acquire additional alterations. Thus, this epigenetic alteration is now considered as a cancer biomarker but could as well play a driving role in multistep cancer development, especially well documented in prostate cancer development. The present review discusses applications of epigenetic alterations affecting GSTP1 in cancer medicine used alone or in combination with other biomarkers for cancer detection and diagnosis as well as for future targeted preventive and therapeutic interventions including by dietary agents.
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影响因子：
9.7
作者：
Duvoix, A;Schnekenburger, M;Diederich, M
通讯作者：
Diederich, M
影响因子：
4.8
作者：
Bakker, J;Lin, XH;Nelson, WG
通讯作者：
Nelson, WG
影响因子：
3.5
作者：
Jhaveri, MS;Morrow, CS
通讯作者：
Morrow, CS
影响因子：
4.1
作者：
Chan, QKY;Khoo, US;Cheung, ANY
通讯作者：
Cheung, ANY
DOI：
10.1016/j.bbrc.2011.08.007
发表时间：
2011-09-09
影响因子：
3.1
作者：
Hauptstock, Vera;Kuriakose, Sapuna;Ellinger, Joerg
通讯作者：
Ellinger, Joerg