Morphometric analysis and clinical followup of isolated prostatic intraepithelial neoplasia in needle biopsy of the prostate.
Morphometric analysis and clinical followup of isolated prostatic intraepithelial neoplasia in needle biopsy of the prostate.
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前列腺穿刺活检中孤立性前列腺上皮内瘤变的形态测量分析和临床随访。
DOI：
10.1097/00005392-199508000-00003
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Catalona,WJ
中科院分区：
文献类型：
--
作者：
Keetch,DW;Humphrey,P;Stahl,D;Smith,DS;Catalona,WJ
PurposeWe评估的意义，孤立的前列腺上皮内瘤样病变的前列腺穿刺活检作为一个预测癌症的重复biopsies.Materials和MethodsWe审查了我们的经验与58名男性50岁或以上谁有孤立的前列腺上皮内瘤样病变的前列腺特异性抗原（PSA）为基础的前列腺癌筛查试验中的初始前列腺穿刺活检。所有58名男性接受重复活检，以跟踪前列腺上皮内瘤变的初步结果。我们评估了患者年龄、直肠指检、血清PSA浓度、PSA密度、前列腺上皮内瘤变分级、肿瘤病灶数量和初次活检标本中前列腺上皮内瘤变的线性范围与重复活检发现癌症的关系。同时对58例有前列腺上皮内瘤变者和427例无前列腺上皮内瘤变者的癌检出率进行了比较（19%）和19（51%）在重复活检时患有癌症（p小于0.02），而在427例初次活检时没有癌症或前列腺上皮内瘤变的患者中有82例（19%）。高级别前列腺上皮内瘤变是重复活检恶性肿瘤的重要预测因子（p> 0.05）。肿瘤病灶的数量和线性范围的前列腺上皮内瘤变的初始活检是没有预测癌症的重复biopsiz.ConclusionsOur结果表明，存在高级别的前列腺上皮内瘤变是一个强有力的预测前列腺癌的男性血清PSA浓度升高，他们应该遵循重复活检。
PurposeWe evaluate the significance of grade and extent of isolated prostatic intraepithelial neoplasia in prostate needle biopsies as a predictor of cancer on repeat biopsy.Materials and MethodsWe reviewed our experience with 58 men 50 years or older who had isolated prostatic intraepithelial neoplasia on initial prostate needle biopsy during a prostate specific antigen (PSA) based screening trial for prostate cancer. All 58 men underwent repeat biopsy to follow the initial findings of prostatic intraepithelial neoplasia. We assessed the relationship of patient age, digital rectal examination, serum PSA concentration, PSA density, prostatic intraepithelial neoplasia grade, number of foci of neoplasia and linear extent of prostatic intraepithelial neoplasia in the initial biopsy specimen to the finding of cancer on the repeat biopsy. We also compared the cancer detection rate in the 58 ment with and 427 without prostatic intraepithelial neoplasia in the same screening trial.ResultsOf 21 men with low grade and 37 with high grade prostatic intraepithelial neoplasia 4 (19 percent) and 19 (51 percent), respectively, had cancer on repeat biopsy (p less than 0.02), compared to 82 of 427 (19 percent) without cancer or prostatic intraepithelial neoplasia on the initial biopsy. High grade prostatic intraepithelial neoplasia was a significant predictor of malignancy on repeat biopsy (p greater than 0.05). The number of foci of neoplasia and the linear extent of prostatic intraepithelial neoplasia on initial biopsy were not predictive of cancer on repeat biopsy.ConclusionsOur results demonstrate that the presence of high grade prostatic intraepithelial neoplasia is a strong predictor of prostate cancer in men with elevated serum PSA concentrations and they should be followed with repeat biopsy.
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静脉尿路造影与放射性核素肾扫描诊断肾损伤的对比研究。
影响因子：
2.1
作者：
S. Flax;G. McLorie;B. Churchill;D. Gilday
通讯作者：
D. Gilday
DOI：
10.2307/2286625
发表时间：
1977
期刊：
The Journal of Urology
影响因子：
--
作者：
J. Bassler;L. A. Marascuilo;M. Mcsweeney
通讯作者：
M. Mcsweeney
高级别前列腺上皮内瘤变对针吸活检的意义。
影响因子：
3.3
作者：
M. Weinstein;J. Epstein
通讯作者：
J. Epstein
使用经直肠超声和前列腺特异性抗原诊断前列腺上皮内瘤变。
影响因子：
2.1
作者：
F. Lee;S. Torp;Carroll Jt;D. Siders;C. Christensen;Mitchell Ae
通讯作者：
Mitchell Ae
前列腺细胞学异型性：频率、分布以及与癌症的可能相关性。
影响因子：
6.6
作者：
R. Oyasu;R. Bahnson;K. Nowels;J. Garnett
通讯作者：
J. Garnett