Reprograming Carcinoma Associated Fibroblasts by microRNAs
Reprograming Carcinoma Associated Fibroblasts by microRNAs
复制标题
通过 microRNA 重编程癌相关成纤维细胞
DOI：
10.2174/1566524018666171205113959
复制
发表时间：
2017
影响因子：
2.5
通讯作者：
Y. Ren
中科院分区：
文献类型：
--
作者：
Y. Xu;X. Zhou;M. Mei;Y. Ren
癌相关成纤维细胞（CAF）是在几种癌症类型的发展过程中活化的成纤维细胞，因此成为癌症治疗的有吸引力的therapeutic.target。PT-100和sibrotuzumab等阻断CAFs功能的药物已经进入临床试验。然而，这些药物在患者中的功效部分是由于目前用于确定功效的生物标志物不是CAF特异性的事实。exhibit.limited此外，CAF的消耗可能通过诱导免疫抑制和缺氧而促进癌发生并加速癌症进展，导致存活率降低。越来越多的证据表明，恢复关键microRNA的表达可以通过靶向不同的信号通路和代谢机制诱导CAFs功能转化为正常的成纤维细胞。因此，通过改变microRNA的特异性表达，而不是靶向消融，将CAFs重新编程为正常成纤维细胞，可能是一种有效的癌症治疗新策略。本文主要综述了参与CAFs转化的特异性microRNA及其在肿瘤发生和化疗耐药中的作用。
Carcinoma-associated fibroblasts (CAFs) are activated fibroblasts during.development of several cancer types, and therefore emerge as an attractive therapeutic.target for cancer therapy. Drugs such as PT-100 and sibrotuzumab that block the.functions of CAFs have already been in clinical trials. However, these drugs exhibit.limited efficacy in patients, partially due to the fact that currently used biomarkers for.determining efficacy are not CAF-specific. Furthermore, depletion of CAFs may promote.carcinogenesis and accelerate cancer progression by inducing immunosuppression and.hypoxia, leading to reduced survival. Accumulating evidence demonstrates that restoring.the expression of key microRNA induces the functional conversion of CAFs into normal.fibroblasts by targeting different signaling pathways and metabolic mechanisms..Therefore, reprograming CAFs into normal fibroblasts by altering specific expression of.microRNAs, rather than targeted ablation, may be an effective, novel strategy for cancer.treatment. This review focuses on specific microRNAs involved in the transformation of.CAFs as well as their multiple roles during tumorigenesis and chemo-resistance.