Depressive symptoms and hippocampal volume in autosomal dominant Alzheimer's disease.
Depressive symptoms and hippocampal volume in autosomal dominant Alzheimer's disease.
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常染色体显性阿尔茨海默病的抑郁症状和海马体积。
DOI：
10.1002/alz.13501
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Gatchel,JenniferR
中科院分区：
文献类型：
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作者：
Langella,Stephanie;Lopera,Francisco;Baena,Ana;Fox-Fuller,JoshuaT;Munera,Diana;Martinez,JairoE;Giudicessi,Averi;Vannini,Patrizia;Hanseeuw,BernardJ;Marshall,GadA;Quiroz,YakeelT;Gatchel,JenniferR
抑郁症状是阿尔茨海默病（AD）的早期行为改变之一；然而，神经退行性变与抑郁症状之间的关系尚无定论。为了更好地理解临床前阿尔茨海默病的这种关系，我们研究了常染色体显性阿尔茨海默病早老素- 1 (PSEN1) E280A突变认知未受损携带者的海马体积和抑郁症状。方法共纳入27例psen1突变携带者和26例非携带者家族成员。采用线性回归检验海马体积与15项老年抑郁量表之间的关系。结果携带者和非携带者在抑郁症状和海马体积上没有差异。在携带者中，较低的海马体积与更大的抑郁症状相关，在调整了年龄和认知后，这一点仍然很明显。这种关系在非携带者中不显著。海马神经退行性变可能是临床前常染色体显性阿尔茨海默病抑郁症状的基础。这些发现为靶向抑郁症状在AD预防中的效用提供了支持。我们比较了未受损的常染色体显性阿尔茨海默病（AD）突变携带者和非携带者。携带者和非携带者在抑郁症状的严重程度上没有差异。在携带者中，海马体积与抑郁症状呈负相关。抑郁症状可能是阿尔茨海默病预防的一个有用的目标。
INTRODUCTIONDepressive symptoms are among early behavioral changes in Alzheimer's disease (AD); however, the relationship between neurodegeneration and depressive symptoms remains inconclusive. To better understand this relationship in preclinical AD, we examined hippocampal volume and depressive symptoms in cognitively unimpaired carriers of the presenilin‐1 (PSEN1) E280A mutation for autosomal dominant AD.METHODSA total of 27PSEN1mutation carriers and 26 non‐carrier family members were included. Linear regression was used to test the relationship between hippocampal volume and 15‐item Geriatric Depression Scale.RESULTSCarriers and non‐carriers did not differ in depressive symptoms or hippocampal volume. Within carriers, lower hippocampal volume was associated with greater depressive symptoms, which remained significant after adjusting for age and cognition. This relationship was not significant in non‐carriers.DISCUSSIONHippocampal neurodegeneration may underlie depressive symptoms in preclinical autosomal dominant AD. These findings provide support for the utility of targeting depressive symptoms in AD prevention.HighlightsWe compared unimpaired autosomal dominant Alzheimer's disease (AD) mutation carriers and non‐carriers.Carriers and non‐carriers did not differ in severity of depressive symptoms.In carriers, hippocampal volume was inversely associated with depressive symptoms.Depressive symptoms may be a useful target in AD prevention.