Essential role for SUN5 in anchoring sperm head to the tail.
Essential role for SUN5 in anchoring sperm head to the tail.
复制标题
SUN5 在将精子头部固定到尾部方面发挥重要作用
作者：
Shang Y;Zhu F;Wang L;Ouyang YC;Dong MZ;Liu C;Zhao H;Cui X;Ma D;Zhang Z;Yang X;Guo Y;Liu F;Yuan L;Gao F;Guo X;Sun QY;Cao Y;Li W
据报道，Sun1和UNC84结构域的蛋白质属于核膜在核动力学中发挥不同的作用，这是太阳家族的新成员，在这里很少了解其功能，我们产生了Sun5 - / - 小鼠。 a揭示了Sun5位于精子的脖子上，将精子固定在尾巴上，而没有实用性的Sun5，精子到尾部耦合的批准是在精子伸长率的过程中与核延长的核素。精子头到尾巴并提供一种有希望的方法来治疗这种鉴别精子相关的男性不育症。
SUN (Sad1 and UNC84 domain containing)-domain proteins are reported to reside on the nuclear membrane playing distinct roles in nuclear dynamics. SUN5 is a new member of the SUN family, with little knowledge regarding its function. Here, we generated Sun5−/− mice and found that male mice were infertile. Most Sun5-null spermatozoa displayed a globozoospermia-like phenotype but they were actually acephalic spermatozoa. Additional studies revealed that SUN5 was located in the neck of the spermatozoa, anchoring sperm head to the tail, and without functional SUN5 the sperm head to tail coupling apparatus was detached from nucleus during spermatid elongation. Finally, we found that healthy heterozygous offspring could be obtained via intracytoplasmic injection of Sun5-mutated sperm heads for both male mice and patients. Our studies reveal the essential role of SUN5 in anchoring sperm head to the tail and provide a promising way to treat this kind of acephalic spermatozoa-associated male infertility.