Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the antiherpes activity of acyclovir
Antiviral activity of 5,6,7-trimethoxyflavone and its potentiation of the antiherpes activity of acyclovir
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DOI：
10.1093/jac/39.6.821
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发表时间：
1997-06-01
影响因子：
5.2
通讯作者：
Takeda, Y
中科院分区：
文献类型：
--
作者：
Hayashi, K;Hayashi, T;Takeda, Y
从日本蒜中分离出一种天然黄酮，5,6,7-三甲氧基黄酮（TMF），进行抗病毒实验。该化合物对1型单纯疱疹病毒（HSV-1）、人巨细胞病毒和脊髓灰质炎病毒具有较高的抑制作用。抗hsv -1的作用不是由于抑制病毒的吸附、进入和病毒蛋白的合成，而可能至少部分地涉及一种杀病毒活性，这种活性导致病毒在早期复制阶段与宿主细胞的结合受到抑制。当抑制浓度低于50%时，TMF和阿昔洛韦的抗hsv活性是协同的。
A naturally occurring flavone, 5,6,7-trimethoxyflavone (TMF), isolated from the plant Callicarpa japonica, was subjected to antiviral assays. The compound exhibited relatively high inhibitory effects on herpes simplex virus type 1 (HSV-1), human cytomegalovirus and poliovirus. The anti-HSV-1 action was not due to the inhibition of virus adsorption, entry and viral protein synthesis, but might involve, at least in part, a virucidal activity, which results in a suppression of viral binding to host cells at an early replication stage. TMF and acylovir were synergic in their anti-HSV activities at levels below the 50% inhibitory concentrations for antiviral activity.