Microbeam studies of the bystander response.
Microbeam studies of the bystander response.
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DOI：
10.1269/jrr.09012s
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发表时间：
2009-03
影响因子：
2
通讯作者：
Shao C
中科院分区：
文献类型：
--
作者：
Prise KM;Schettino G;Vojnovic B;Belyakov O;Shao C
自60年代中期引入和早期使用以来，微光束经历了一次复兴。最近在成像、软件和光束传输方面的进展使得微光束在一系列实验研究中使用的技术迅速发展。自上世纪90年代中期以来，微光束的使用重新兴起，与我们对辐射如何与细胞相互作用的理解发生了重大变化。特别是，旁观者反应发生的证据，即没有直接辐照的细胞可以对辐照的邻居作出反应，带来了辐射反应新模型的发展。尽管这些过程已经使用一系列实验方法进行了研究，但微光束提供了一种独特的途径，可以阐明旁观者的反应。无一例外，目前国际上所有活跃的微光束都在一系列细胞和组织模型中研究了旁观者反应。总之，这些研究大大提高了我们对旁观者反应和基础机制的认识。其中大部分来自带电粒子微束研究，但x射线和电子微束越来越多地开始提供旁观者效应的定量和机制信息。最近的一项发展是从二维细胞培养模型的研究转向更复杂的三维系统，其中利用微光束在空间和时间传递方面的独特特性的可能性将产生重大影响。
Microbeams have undergone a renaissance since their introduction and early use in the mid 60s. Recent advances in imaging, software and beam delivery have allowed rapid technological developments in microbeams for use in a range of experimental studies. The resurgence in the use of microbeams since the mid 90s has coincided with major changes in our understanding of how radiation interacts with cells. In particular, the evidence that bystander responses occur, where cells not directly irradiated can respond to irradiated neighbours, has brought about the evolution of new models of radiation response. Although these processes have been studied using a range of experimental approaches, microbeams offer a unique route by which bystander responses can be elucidated. Without exception, all of the microbeams currently active internationally have studied bystander responses in a range of cell and tissue models. Together these studies have considerably advanced our knowledge of bystander responses and the underpinning mechanisms. Much of this has come from charged particle microbeam studies, but increasingly, X-ray and electron microbeams are starting to contribute quantitative and mechanistic information on bystander effects. A recent development has been the move from studies with 2-D cell culture models to more complex 3-D systems where the possibilities of utilizing the unique characteristics of microbeams in terms of their spatial and temporal delivery will make a major impact.
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影响因子：
8.8
作者：
Chen, S.;Zhao, Y.;Han, W.;Zhao, G.;Zhu, L.;Wang, J.;Bao, L.;Jiang, E.;Xu, A.;Hei, T. K.;Yu, Z.;Wu, L.
通讯作者：
Wu, L.
影响因子：
8.8
作者：
Belyakov OV;Malcolmson AM;Folkard M;Prise KM;Michael BD
通讯作者：
Michael BD
DOI：
10.1016/j.mrfmmm.2007.02.005
发表时间：
2007-06-01
影响因子：
2.3
作者：
Kashino, Genro;Suzuki, Keiji;Prise, Kevin M.
通讯作者：
Prise, Kevin M.
DOI：
10.1016/j.mrfmmm.2005.08.012
发表时间：
2006-05-11
影响因子：
2.3
作者：
Belyakov, Oleg V.;Folkard, Melvyn;Michael, Barry D.
通讯作者：
Michael, Barry D.
影响因子：
8
作者：
Burdak-Rothkamm, S.;Short, S. C.;Prise, K. M.
通讯作者：
Prise, K. M.