Conopeptide characterization and classifications: An analysis using ConoServer
Conopeptide characterization and classifications: An analysis using ConoServer
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DOI：
10.1016/j.toxicon.2010.03.002
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发表时间：
2010-07-01
期刊：
影响因子：
2.8
通讯作者：
Craik, David J.
中科院分区：
文献类型：
--
作者：
Kaas, Quentin;Westermann, Jan-Christoph;Craik, David J.
锥螺是肉食性海洋腹足类动物，进化出强大的毒液来捕获猎物。这些毒液包含丰富多样的肽毒素或芋螺肽混合物，其高度多样性源于高效的超突变机制，结合高频率的翻译后修饰。芋螺肽与中枢和肌肉神经系统的不同膜受体、离子通道和转运蛋白高度特异性结合。除了在猎物捕获中发挥其天然功能外，芋螺肽已被用作神经科学中的通用工具，并已被证明是靶向人类神经系统的药物先导物。本文基于ConoServer（http：//www.example.com）中的基因和肽序列的分析来检查当前关于芋螺肽序列的知识，ConoServer是芋螺肽序列和三维结构的专门数据库。www.conoserven.org我们描述了更新的内容和组织的ConoServer和讨论基因超家族，半胱氨酸框架，药理学家族的conopeptides，和coneptides，栖息地和饮食的锥螺之间的相关性。该研究确定了目前对锥肽的认识的差距，并指出了未来研究的潜在方向。(C)2010爱思唯尔有限公司保留所有权利。
Cone snails are carnivorous marine gastropods that have evolved potent venoms to capture their prey. These venoms comprise a rich and diverse cocktail of peptide toxins, or conopeptides, whose high diversity has arisen from an efficient hypermutation mechanism, combined with a high frequency of post-translational modifications. Conopeptides bind with high specificity to distinct membrane receptors, ion channels, and transporters of the central and muscular nervous system. As well as serving their natural function in prey capture, conopeptides have been utilized as versatile tools in neuroscience and have proven valuable as drug leads that target the nervous system in humans. This paper examines current knowledge on conopeptide sequences based on an analysis of gene and peptide sequences in ConoServer (http://www.conoserven.org), a specialized database of conopeptide sequences and three-dimensional structures. We describe updates to the content and organization of ConoServer and discuss correlations between gene super-families, cysteine frameworks, pharmacological families targeted by conopeptides, and the phylogeny, habitat, and diet of cone snails. The study identifies gaps in current knowledge of conopeptides and points to potential directions for future research. (C) 2010 Elsevier Ltd. All rights reserved.