SYNTHESIS AND OPTICAL RESOLUTION OF HIGH-AFFINITY P-2-LIGANDS FOR HIV-1 PROTEASE INHIBITORS
SYNTHESIS AND OPTICAL RESOLUTION OF HIGH-AFFINITY P-2-LIGANDS FOR HIV-1 PROTEASE INHIBITORS
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DOI：
10.1016/0040-4039(94)02296-n
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发表时间：
1995-01-23
影响因子：
1.8
通讯作者：
CHEN, Y
中科院分区：
文献类型：
--
作者：
GHOSH, AK;CHEN, Y
利用钴肟10催化自由基环化反应作为关键步骤，高效合成了外消旋双四氢呋喃配体6。用固定化Amano脂肪酶拆分外消旋醇，得到光学纯的配体。
Racemic bis-tetrahydrofuran ligand 6 was efficiently synthesized utilizing catalytic cobaloxime 10 mediated radical cyclization as the key step. Optical resolution of the racemic alcohol with immobilized-Amano lipase, afforded optically pure ligands.