Exogenous leptin influences gastrointestinal growth and in vitro small intestinal motility in neonatal piglets - preliminary results
Exogenous leptin influences gastrointestinal growth and in vitro small intestinal motility in neonatal piglets - preliminary results
复制标题
外源瘦素影响新生仔猪胃肠道生长和体外小肠蠕动 - 初步结果
DOI：
10.22358/jafs/70069/2001
复制
发表时间：
2001
影响因子：
1
通讯作者：
R. Zabielski
中科院分区：
文献类型：
--
作者：
J. Woliński;V. Naughton;M. Biernat;M. Bábelewska;W. Korczyniski;R. Zabielski
将8头初生仔猪随机分为两组。所有的仔猪都被喂以“人造母猪”的牛奶代用品。每日3次，连续6天，给予生理盐水(对照组，n=5)或瘦素(10 mg/kg体重溶于生理盐水)(实验组，n=3)灌胃。然后对仔猪进行解剖，切除整个胃肠道，并采集十二指肠和空肠中段的碎片，测量它们的体外运动。尽管体重没有差异，但服用瘦素的仔猪在胃和胰腺的重量以及回肠长度方面与对照组相比存在差异。瘦素的应用也以特定节段特有的方式显著影响肠道运动(分别为P<；0.05；P<；0.01；P<；0.001)。瘦素组仔猪十二指肠自发收缩及对乙酰胆碱和异丙肾上腺素的反应性高于对照组，而空肠段则相反。为了在更多的动物身上证实这些结果，实验将继续进行。
Eight newborn piglets were randomly assigned to two groups. All of the piglets were fed with a milk replacer using an ``artificial sow''. Three limes daily for six days they received physiological saline (0.9% NaCl) (control group, n=5) or leptin at 10 mug/kg body weight dissolved in physiological saline (experimental group, n=3) administered intragastrically. The piglets were then anaethesized, the entire gastrointestinal tract removed, and fragments of the duodenum and mid-jejunum were harvested and their in vitro motility was measured. Despite lack of differences in body weight, the piglets treated with leptin showed differences in the weight of the stomach and pancreas and length of the ileum in comparison with the controls. Administration of leptin also significantly affected intestinal motility in a manner characteristic of the particular segments (P <0.05; P <0.01; P <0.001, respectively). The spontaneous contractions of the duodenum and its response to acetylcholine and isoproterenol were higher in the group of piglets treated with leptin than in controls, whereas segments of the jejunum behaved in the opposite manner. The experiments will be continued in order to confirm these results on a larger number of animals.
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
通讯作者：
--