Expression of prostate specific membrane antigen (PSMA) in prostatic adenocarcinoma and prostatic intraepithelial neoplasia
Expression of prostate specific membrane antigen (PSMA) in prostatic adenocarcinoma and prostatic intraepithelial neoplasia
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DOI：
10.14670/hh-19.715
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发表时间：
2004-07-01
影响因子：
2
通讯作者：
Boswick, DG
中科院分区：
文献类型：
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作者：
Marchal, C;Redondo, M;Boswick, DG
前列腺膜抗原（PSMA）是在前列腺上皮中表达的蛋白质。我们研究了一系列的55例不同阶段的前列腺癌患者的PSMA的表达，我们比较了前列腺癌细胞中的PSMA染色，在高级别的前列腺上皮内瘤变（PIN）和组织学良性前列腺上皮相同的标本。为此，采用链霉亲和素-生物素法，用抗PSMA的单克隆抗体7 E11-C5.3通过免疫组织化学对存档石蜡包埋标本进行研究。前列腺癌（CaP）细胞和PIN细胞中PSMA的平均阳性率分别为56.67%和48.6%，显著高于良性前列腺上皮（5.72%）（每对细胞均为P
The prostatic membrane antigen (PSMA) is a protein that is expressed in the prostatic epithelium. We studied the expression of PSMA in a series of 55 patients with different stages of prostate cancer and we compared the PSMA staining in prostate cancer cells, in high-grade prostatic intraepithelial neoplasia (PIN) and in histologically benign prostatic epithelium for the same specimen. For this purpose archival paraffin-embedded specimens were studied by immunohistochemistry with a monoclonal antibody 7E11-C5.3 against PSMA using the streptavidin-biotin method. The mean percentage of PSMA immunoreactivity was 56.67% in prostate cancer (CaP) cells, and 48.6% in PIN cells, which was significantly higher than benign-appearing prostatic epithelium (5.72%) (for each pair, p