A genetically determined dose-volume histogram predicts for rectal bleeding among patients treated with prostate brachytherapy
A genetically determined dose-volume histogram predicts for rectal bleeding among patients treated with prostate brachytherapy
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DOI：
10.1016/j.ijrobp.2007.02.052
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发表时间：
2007-08-01
影响因子：
7
通讯作者：
Rosenstein, Barry S.
中科院分区：
文献类型：
--
作者：
Cesaretti, Jamie A.;Stock, Richard G.;Rosenstein, Barry S.
Purpose: To examine whether possession of genetic alterations in the A TM (ataxia telangiectasia) gene is associated with rectal bleeding in a dose-dependent and volume-dependent manner.Methods and Materials: One hundred eight prostate cancer patients who underwent brachytherapy using either an I-125 implant, a Pd-103 implant, or the combination of external beam radiotherapy with a Pd-103 implant and had a minimum of 1 year follow-up were screened for DNA sequence variations in the 62 coding exons of the ATM gene using denaturing high-performance liquid chromatography. Rectal dose was reported as the volume (in cubic centimeters) of rectum receiving the brachytherapy prescription dose. The two-sided Fisher exact test was used to compare differences in proportions.Results: A significant correlation between the presence of any ATM sequence alteration and Grade 1 to 2 proctitis was obtained when the radiation dose to rectal tissue was quantified. Rectal bleeding occurred in 4 of 13 patients (31 %) with a variant versus 1 of 23 (4%) without a genetic alteration for patients who had
