Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia
Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia
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DOI：
10.1093/brain/awn049
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发表时间：
2008-06-01
期刊：
影响因子：
14.5
通讯作者：
Satlin, Andrew
中科院分区：
文献类型：
--
作者：
Harper, David G.;Stopa, Edward G.;Satlin, Andrew
视交叉上核（SCN）是维持灵长类和其他哺乳动物昼夜节律所必需的。人背内侧SCN含有非种属特异性的加压素和种属特异性的神经降压素神经元。我们对19名老年男性终末期痴呆患者和8名正常老年对照者的核心体温和自发活动进行了时间序列记录。痴呆患者死亡后，获得神经病理学诊断信息和下丘脑组织样本。下丘脑组织也从8个正常对照病例中获得，这些病例以前没有活动或核心温度记录。核心温度进行了分析的参数，昼夜节律的功能，并分析了非参数和参数昼夜节律功能的活动。然后将这些指数与SCN中观察到的变性程度（胶质细胞/神经元比率）和背内侧SCN的神经元计数（加压素、神经降压素）相关。SCN神经降压素神经元的特定损失与活动和温度幅度的损失相关，而不增加活动碎片。SCN加压素神经元的损失与活动碎片的增加有关，但与振幅的损失无关。在痴呆病例中观察到血管加压素活性昼夜节律的证据，但没有观察到神经降压素活性昼夜节律的证据。这些结果提供的证据表明，SCN是必要的，以维持人类的昼夜节律，信息的作用，神经元亚群subserving这一功能和效用的痴呆症在阐述人类的脑行为关系。
The suprachiasmatic nuclei (SCN) are necessary and sufficient for the maintenance of circadian rhythms in primate and other mammalian species. The human dorsomedial SCN contains populations of non-species-specific vasopressin and species-specific neurotensin neurons. We made time-series recordings of core body temperature and locomotor activity in 19 elderly, male, end-stage dementia patients and 8 normal elderly controls. Following the death of the dementia patients, neuropathological diagnostic information and tissue samples from the hypothalamus were obtained. Hypothalamic tissue was also obtained from eight normal control cases that had not had activity or core temperature recordings previously. Core temperature was analysed for parametric, circadian features, and activity was analysed for non-parametric and parametric circadian features. These indices were then correlated with the degree of degeneration seen in the SCN (glia/neuron ratio) and neuronal counts from the dorsomedial SCN (vasopressin, neurotensin). Specific loss of SCN neurotensin neurons was associated with loss of activity and temperature amplitude without increase in activity fragmentation. Loss of SCN vasopressin neurons was associated with increased activity fragmentation but not loss of amplitude. Evidence for a circadian rhythm of vasopressinergic activity was seen in the dementia cases but no evidence was seen for a circadian rhythm in neurotensinergic activity. These results provide evidence that the SCN is necessary for the maintenance of the circadian rhythm in humans, information on the role of neuronal subpopulations in subserving this function and the utility of dementia in elaborating brainbehaviour relationships in the human.