A pan-cancer analysis of the oncogenic role of staphylococcal nuclease domain-containing protein 1 (SND1) in human tumors
A pan-cancer analysis of the oncogenic role of staphylococcal nuclease domain-containing protein 1 (SND1) in human tumors
复制标题
含葡萄球菌核酸酶结构域蛋白 1 (SND1) 在人类肿瘤中致癌作用的泛癌分析
DOI：
10.1016/j.ygeno.2020.06.044
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发表时间：
2020-11-01
期刊：
影响因子：
4.4
通讯作者：
Yang, Jie
中科院分区：
文献类型：
--
作者：
Cui, Xiaoteng;Zhang, Xinxin;Yang, Jie
尽管新出现的基于细胞或动物的证据支持SND1与癌症之间的关系，但尚无泛癌症分析可用。因此，我们首先基于TCGA(癌症基因组图谱)和GEO(基因表达总集)的数据集，探索SND1在33种肿瘤中的潜在致癌作用。SND1在大多数肿瘤中都有高表达，并且与肿瘤患者的预后有明显的相关性。我们观察到S426在一些肿瘤中的磷酸化水平增强，例如乳腺癌或肺腺癌。在结肠腺癌和黑色素瘤中，SND1的表达与CD8(+)T细胞的浸润程度有关，在其他肿瘤中，如膀胱尿路上皮癌或睾丸生殖细胞肿瘤中也可观察到癌相关成纤维细胞的浸润。此外，蛋白质加工和RNA代谢相关的功能也参与了SND1的作用机制。我们的第一项泛癌症研究提供了一个相对全面的理解SND1在不同肿瘤中的致癌作用。
Although emerging cell- or animal-based evidence supports the relationship between SND1 and cancers, no pan-cancer analysis is available. We thus first explored the potential oncogenic roles of SND1 across thirty-three tumors based on the datasets of TCGA (The cancer genome atlas) and GEO (Gene expression omnibus). SND1 is highly expressed in most cancers, and distinct associations exist between SND1 expression and prognosis of tumor patients. We observed an enhanced phosphorylation level of S426 in several tumors, such as breast cancer or lung adenocarcinoma. SND1 expression was associated with the CD8(+) T-cell infiltration level in colon adenocarcinoma and melanoma, and cancer-associated fibroblast infiltration was observed in other tumors, such as bladder urothelial carcinoma or testicular germ cell tumors. Moreover, protein processing- and RNA metabolism-associated functions were involved in the functional mechanisms of SND1. Our first pan-cancer study offers a relatively comprehensive understanding of the oncogenic roles of SND1 across different tumors.