Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardial infarction
Usefulness of adiponectin to predict myocardial salvage following successful reperfusion in patients with acute myocardial infarction
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DOI：
10.1016/j.amjcard.2008.02.057
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发表时间：
2008-06-15
影响因子：
2.8
通讯作者：
Murohara, Toyoaki
中科院分区：
文献类型：
--
作者：
Shibata, Rei;Numaguchi, Yasushi;Murohara, Toyoaki
脂联素是一种脂肪来源的血浆蛋白，在缺血条件下对心肌损伤具有有益的作用。据报道，循环内皮祖细胞与急性心肌梗死(AMI)后心脏损伤的抢救有关。我们研究了循环脂联素水平是否影响急性心肌梗死患者的心肌功能和损伤。入选48例急性心肌梗死后再通成功的患者。急性期用~(123)I-β-甲基苯基十五烷酸显像评价心功能，远期用~(99m)Tfosmin显像评价心功能和血流灌注缺陷。用双抗体夹心法测定急性心肌梗死后第7天的血浆脂联素水平。血浆脂联素水平与心肌挽救指数呈正相关，与终末期心肌梗死面积呈负相关。脂联素水平与心肌挽救指数呈正相关，与远期射血分数恢复呈负相关。脂联素水平与循环CD34(+)细胞数呈正相关，心肌挽救指数与射血分数恢复独立与循环CD34(+)细胞水平相关。综上所述，血浆脂联素水平可预测急性心肌梗死患者再通治疗后心脏损害和功能的改善，提示脂联素可作为评价急性心肌梗死后心肌损伤的生物标志物。(C)2008 Elsevier Inc.保留所有权利。
Adiponectin is an adipose-derived plasma protein that demonstrates beneficial actions on myocardial injury under ischemic conditions. Circulating endothelial progenitor cells are reported to associate with rescue of cardiac damage after acute myocardial infarction (AMI). We examined whether circulating adiponectin level affects myocardial function and injury in patients with AMI. A total of 48 patients who underwent successful reperfusion treatment after AMI were enrolled. Cardiac function and perfusion defect were assessed by scintigraphic images of iodine-123 beta-methyl iodophenyl pentadecanoic acid in the acute phase and technetium-99m tetrofosmin in the long-term phase. Plasma adiponectin levels were measured by enzyme-linked immunosorbent assay at day 7 after AMI. Plasma adiponectin levels associated positively with myocardial salvage index representing the proportion of initial perfusion defect rescued by reperfusion and recovery of ejection fraction in the long-term phase and negatively with final infarct size. A positive correlation was also observed between adiponectin levels and number of circulating CD34(+) cells as determined by How cytometry and between myocardial salvage index and recovery of ejection fraction independently associated with circulating CD34(+) cell levels. In conclusion, plasma adiponectin levels predict improvement of cardiac damage and function after reperfusion therapy in patients with AMI, suggesting that adiponectin could serve as a biomarker for assessment of myocardial injury after AMI. (c) 2008 Elsevier Inc. All rights reserved.