Chemokines and asthma: redundancy of function or a coordinated effort?
Chemokines and asthma: redundancy of function or a coordinated effort?
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DOI：
10.1172/jci8125
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发表时间：
1999-10-01
影响因子：
15.9
通讯作者：
Hogaboam, CM
中科院分区：
文献类型：
--
作者：
Lukacs, NW;Oliveira, SHP;Hogaboam, CM
解释这些细胞招募的特殊性的观点(14-16)。有趣的是，嗜酸性粒细胞趋化因子可通过β1和β2整合素介导的机制，在剪切力作用下诱导嗜酸性粒细胞与内皮细胞结合增加，提示嗜酸性粒细胞迁移功能的几个方面受到影响(17)。在人类哮喘中，嗜酸性粒细胞趋化因子产生水平较高，并定位于呼吸道上皮细胞。这种集中的表达可能优先将嗜酸性粒细胞定位于上皮细胞，并诱导脱颗粒，导致上皮损伤蛋白的释放。除了招募和激活嗜酸性粒细胞外，嗜酸性粒细胞趋化因子还可以影响其他细胞群。嗜碱性粒细胞在嗜酸性粒细胞存在的情况下脱颗粒，而Th2型细胞可以向嗜酸性粒细胞迁移。因此，嗜酸性粒细胞趋化因子可能是治疗干预的主要靶点。许多其他趋化因子及其受体也可能为治疗干预提供重要的靶点，因为它们能够招募和激活其他重要的细胞群体进入呼吸道及其周围。下面将讨论这些趋化因子及其受体。
Perspective explaining the specificity of the recruitment of these cells (14–16). Interestingly, eotaxin can induce increased binding of eosinophils under shear force to endothelium via β1 and β2 integrin–mediated mechanisms, suggesting that eotaxin can affect several aspects of eosinophil migratory functions (17). In human asthma, eotaxin is produced at high levels and localized to the airway epithelium. This concentrated expression may preferentially target eosinophils to the epithelium and induce degranulation leading to the release of epithelium-damaging proteins. In addition to recruiting and activating eosinophils, eotaxin can effect other cell populations. Basophils degranulate in the presence of eotaxin, while Th2-type cells can migrate toward eotaxin. Thus, eotaxin may be a primary target for therapeutic intervention. A number of other chemokines and their receptors may also provide significant targets for therapeutic intervention because of their ability to recruit and activate other important cell populations into and around the airway. These chemokines and their receptors are discussed below.