PROTCOM: searchable database of protein complexes enhanced with domain-domain structures
PROTCOM: searchable database of protein complexes enhanced with domain-domain structures
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DOI：
10.1093/nar/gkl768
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发表时间：
2007-01-01
影响因子：
14.9
通讯作者：
Alexov, Emil
中科院分区：
文献类型：
--
作者：
Kundrotas, Petras J.;Alexov, Emil
蛋白质复合物数据库 (PROTCOM) 是蛋白质-蛋白质复合物已知 3D 结构的汇编，其中富含使用蛋白质数据库中的可用条目人工创建的域-域结构。域-域结构是通过将单链结构解析为松散连接的域而生成的，是数据库的重要特征。该数据库 (http://www.ces.clemson.edu/compbio/protcom) 可用于对接和其他预测蛋白质-蛋白质复合物 3D 结构的算法的基准测试。该数据库可用作同源或线程方法中的模板数据库，用于建模未知蛋白质-蛋白质复合物的 3D 结构。 PROTCOM 为科学界提供了一套集成的工具，用于浏览、搜索、可视化和下载蛋白质复合物库。用户可以选择使用最多 10 个不同标准的组合来选择条目子集。截至 2006 年 7 月，该数据库包含 1770 个条目，每个条目都包含已知的 3D 结构和可以以纯文本或视觉模式显示的附加相关信息。
The database of protein complexes (PROTCOM) is a compilation of known 3D structures of protein-protein complexes enriched with artificially created domain-domain structures using the available entries in the Protein Data Bank. The domain-domain structures are generated by parsing single chain structures into loosely connected domains and are important features of the database. The database (http://www.ces.clemson.edu/compbio/protcom) could be used for benchmarking purposes of the docking and other algorithms for predicting 3D structures of protein-protein complexes. The database can be utilized as a template database in the homology or threading methods for modeling the 3D structures of unknown protein-protein complexes. PROTCOM provides the scientific community with an integrated set of tools for browsing, searching, visualizing and downloading a pool of protein complexes. The user is given the option to select a subset of entries using a combination of up to 10 different criteria. As on July 2006 the database contains 1770 entries, each of which consists of the known 3D structures and additional relevant information that can be displayed either in text-only or in visual mode.