Optimization of nanoparticle core size for magnetic particle imaging.

Optimization of nanoparticle core size for magnetic particle imaging.
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DOI:
10.1016/j.jmmm.2009.02.083
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发表时间:
2009
影响因子:
2.7
通讯作者:
Krishnan KM
Krishnan KM
中科院分区:
材料科学3区
文献类型:
--
作者:
Ferguson RM;Minard KR;Krishnan KM

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磁性粒子成像(MPI)是一种强大的新型研究和诊断成像平台,旨在对生物组织中超顺磁性纳米粒子的数量和位置进行成像。在这里,我们提出了数学建模结果,显示MPI的灵敏度和空间分辨率都取决于纳米颗粒核心的大小和其他物理特性,以及如何通过合理的核心设计,可以有效地优化成像性能。使用磁铁矿核心的属性进行建模,因为这些很容易产生一个可控的大小,便于定量成像。结果表明,非常低的检测阈值(几纳克Fe3O4)和亚毫米空间分辨率是可能的MPI。
Magnetic particle imaging (MPI) is a powerful new research and diagnostic imaging platform that is designed to image the amount and location of superparamagnetic nanoparticles in biological tissue. Here, we present mathematical modeling results that show how MPI sensitivity and spatial resolution both depend on the size of the nanoparticle core and its other physical properties, and how imaging performance can be effectively optimized through rational core design. Modeling is performed using the properties of magnetite cores, since these are readily produced with a controllable size that facilitates quantitative imaging. Results show that very low detection thresholds (of a few nanograms Fe3O4) and sub-millimeter spatial resolution are possible with MPI.
DOI: 10.1002/cmr.1008
发表时间: 2001-01-01
期刊: CONCEPTS IN MAGNETIC RESONANCE
影响因子: --
作者:
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通讯作者: Wind, RA
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