Antidepressants regulate autophagy by targeting acid sphingomyelinase
Antidepressants regulate autophagy by targeting acid sphingomyelinase
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抗抑郁药通过靶向酸性鞘磷脂酶调节自噬
DOI：
10.1038/s41380-018-0319-7
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发表时间：
2018
影响因子：
11
通讯作者：
E. Gulbins
中科院分区：
文献类型：
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作者：
Anne Gulbins;F. Schumacher;K. A. Becker;B. Wilker;Matthias Soddemann;F. Boldrin;C. Müller;M. Edwards;Michael Goodman;C. Caldwell;B. Kleuser;J. Kornhuber;I. Szabó;E. Gulbins
图1野生型（wt）和酸性鞘磷脂酶（Asm）缺陷小鼠（Smpd 1-/-）未接受治疗或按指示进行治疗。分离每只小鼠的海马并进行透射电子显微镜分析。皮质酮（Cort）应激减少自噬。阿米替林（Amitriptyline，Ami）和D 609诱导未应激或应激的野生型小鼠海马神经元的自噬。阿米替林对Asm缺陷细胞没有影响，而D 609也诱导这些小鼠海马神经元的自噬。早期和晚期自噬体用红色箭头指示，早期和晚期自噬溶酶体用黄色箭头指示。缩写是：M，线粒体; N，细胞核; Ax：髓鞘包围的轴突。欲了解更多信息，请参见Gulbins等人的文章，第2324-2346页
Fig. 1 Wild-type (wt) and acid sphingomyelinase (Asm)-deficient mice (Smpd1−/−) were left untreated or were treated as indicated. The hippocampus of each mouse was isolated and subjected to analysis with transmission electron microscopy. Corticosterone (Cort) stress reduces autophagy. Amitriptyline (Ami) and D609 induce autophagy in hippocampal neurons of unstressed or stressed wild-type mice.Amitriptyline has no effect in Asm-deficient cells, while D609 induces autophagy also in hippocampus neurons of these mice. Early and late autophagosomes are indicated with red arrows, early and late autophagolysosomes with yellow arrows. Abbreviations are: M, mitochondria; N, nucleus; Ax: myelin-surrounded axon. For more information see the article by Gulbins et al on pages 2324–2346