Genome-wide association scan for five major dimensions of personality.
Genome-wide association scan for five major dimensions of personality.
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DOI：
10.1038/mp.2008.113
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发表时间：
2010-06
影响因子：
11
通讯作者：
中科院分区：
文献类型：
--
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人格特质由五个广泛的维度概括，对主要生活结果具有普遍影响，与精神疾病有密切联系，并且具有明确的遗传成分。为了识别与人格的五个维度中的每一个相关的遗传变异，我们对来自意大利撒丁岛的遗传隔离人群的3,972个个体进行了全基因组关联（GWA）扫描。基于对362，129个单核苷酸多态性（SNP）的分析，我们在先前与精神疾病有关的基因内或附近发现了几个强信号。他们包括神经质与SNAP 25的关联（rs362584，P = 5 × 10−5），BDNF和两个钙粘蛋白基因的外向性（CDH 13和CDH 23; Ps < 5 × 10−5），CNTNAP的开放性2（rs 10251794，P = 3 × 10−5），与时钟（rs6832769，P = 9 × 10−6）和与DYRK 1A（rs 2835731，P = 3 × 10−5）的责任感。效应量很小（小于1%的方差），并且大多数在后续独立样本中未能复制（N高达3，903），尽管在三个重复样本中有两个支持可重复性和时钟之间的关联（总体P = 2 × 10−5）。我们推断，大量的基因座可能会影响人格特质和障碍，需要更大的样本量的GWA方法来确定显着的遗传变异。
Personality traits are summarized by five broad dimensions with pervasive influences on major life outcomes, strong links to psychiatric disorders, and clear heritable components. To identify genetic variants associated with each of the five dimensions of personality we performed a genome wide association (GWA) scan of 3,972 individuals from a genetically isolated population within Sardinia, Italy. Based on analyses of 362,129 single nucleotide polymorphisms (SNPs) we found several strong signals within or near genes previously implicated in psychiatric disorders. They include the association of Neuroticism with SNAP25 (rs362584, P = 5 × 10−5), Extraversion with BDNF and two cadherin genes (CDH13 and CDH23; Ps < 5 × 10−5), Openness with CNTNAP2 (rs10251794, P = 3 × 10−5), Agreeableness with CLOCK (rs6832769, P = 9 × 10−6), and Conscientiousness with DYRK1A (rs2835731, P = 3 × 10−5). Effect sizes were small (less than 1% of variance), and most failed to replicate in the follow-up independent samples (N up to 3,903), though the association between Agreeableness and CLOCK was supported in two of three replication samples (overall P = 2 × 10−5). We infer that a large number of loci may influence personality traits and disorders, requiring larger sample sizes for the GWA approach to identify significant genetic variants.
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影响因子：
3.5
作者：
Altafaj, X;Dierssen, M;Estivill, X
通讯作者：
Estivill, X
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通讯作者：
Abecasis, Goncalo R.
影响因子：
9.8
作者：
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通讯作者：
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