Selectivity in the ruthenium-catalyzed alder ene reactions of di- and triynes
Selectivity in the ruthenium-catalyzed alder ene reactions of di- and triynes
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DOI：
10.1021/ja0719430
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发表时间：
2007-05-30
影响因子：
15
通讯作者：
Lee, Daesung
中科院分区：
文献类型：
--
作者：
Cho, Eun Jin;Lee, Daesung
钌催化二炔和三炔与末端烯烃之间的醛烯反应，得到相应的烯炔和烯炔具有较高的区域选择性和位点选择性。选择性谱清楚地表明，1,3-二炔的一个炔基部分不参与反应决定了区域化学，而空间位阻和丙炔基上的极性取代基之间的相互作用决定了位点选择性。
Ruthenium-catalyzed Alder ene reactions between diynes and triynes with terminal alkenes gave the corresponding enynes and enediynes with high regio- and site-selectivity. The selectivity profile clearly indicates that one of the alkynyl moieties of 1,3-diynes not participating in the reaction determines the regiochemistry, whereas the interplay between steric hindrance and polar substituents at the propargylic sites determines the site-selectivity.