DNA replication timing data corroborate in silico human replication origin predictions
DNA replication timing data corroborate in silico human replication origin predictions
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DOI：
10.1103/physrevlett.99.248102
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发表时间：
2007-12-14
影响因子：
8.6
通讯作者：
Arneodo, A.
中科院分区：
文献类型：
--
作者：
Audit, B.;Nicolay, S.;Arneodo, A.
我们开发了一种基于小波的多尺度模式识别方法来解开复制-从人类基因组中观察到的转录相关的组成链不对称性。比较复制偏斜配置文件最近的高分辨率复制时序数据显示，大多数假定的复制起点，边界的复制域复制早于他们的周围，而中央区域复制晚在S期。我们讨论了这些复制起点的预测，可能是早期复制和活跃在大多数组织中的第一次实验确认的影响。
We develop a wavelet-based multiscale pattern recognition methodology to disentangle the replication- from the transcription-associated compositional strand asymmetries observed in the human genome. Comparing replication skew profiles to recent high-resolution replication timing data reveals that most of the putative replication origins that border the so-identified replication domains are replicated earlier than their surroundings whereas the central regions replicate late in the S phase. We discuss the implications of this first experimental confirmation of these replication origin predictions that are likely to be early replicating and active in most tissues.