Association of dietary and serum magnesium with glucose metabolism markers: The Furukawa Nutrition and Health Study
Association of dietary and serum magnesium with glucose metabolism markers: The Furukawa Nutrition and Health Study
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DOI：
10.1016/j.clnesp.2018.01.011
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发表时间：
2018-04-01
影响因子：
3
通讯作者：
Mizoue, Tetsuya
中科院分区：
文献类型：
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作者：
Akter, Shamima;Eguchi, Masafumi;Mizoue, Tetsuya
背景和目标：镁可能在包括2型糖尿病在内的心脏代谢异常中发挥重要作用，但在亚洲人中将镁状态与葡萄糖代谢联系起来的流行病学证据有限。我们横断面研究了饮食和血清镁与日本subjects.Methods的葡萄糖代谢标志物的关联：受试者为1796名工人，年龄在18-78岁，谁参加了健康调查。膳食镁的摄入量采用经过验证的饮食史问卷进行评估。血清镁浓度测定使用酶法。多变量线性回归模型被用来估计空腹胰岛素，空腹血糖，稳态模型评估胰岛素抵抗（HOMA-IR），稳态模型评估β细胞功能（HOMA-beta），糖化血红蛋白（HbA 1c）的平均值，调整潜在的混杂变量。结果：膳食镁与HOMA-IR呈负相关（P-趋势= 0.01）。膳食镁最低至最高四分位数的HOMA-IR多变量调整均值（95%置信区间）为0.94（0.89-0.99）、0.92（0.88-0.97）、0.88（0.83-0.92）和0.86（0.81-0.90）。血清镁浓度也与HOMA-IR（P趋势= 0.04）和HbA 1c（P趋势< 0.01）呈负相关。多变量调整均值血清镁的最低至最高四分位数（95%置信区间）为0.94（0.90-0.98）、0.87 HOMA-IR为0.83-0.91）、0.90（0.85-0.95）和0.86（0.81-0.92），HbA 1c为5.41（5.36-5.45）、5.33（5.28-5.37）、5.30（5.25-5.36）和5.28（5.22-5.35）。排除糖尿病受试者并没有实质性改变膳食镁和HOMA-IR之间的关联（P趋势< 0.01），但它减弱了血清镁与HOMA-IR（P趋势= 0.27）和HbA 1c（P趋势= 0.15）的关联。结论：目前的研究结果表明，在表面健康的成年人中，较低的膳食镁，而不是血清镁，与IR相关。(c)2018年欧洲临床营养与代谢学会。由爱思唯尔有限公司出版。保留所有权利。
Background & aims: Magnesium may play an important role in cardio-metabolic abnormalities, including type 2 diabetes, but epidemiological evidence linking magnesium status to glucose metabolism is limited among Asians. We cross-sectionally examined the association of dietary and serum magnesium with markers of glucose metabolism among Japanese subjects.Methods: Subjects were 1796 workers, aged 18-78 years, who participated in a health survey. Dietary magnesium intake was assessed with a validated brief diet history questionnaire. Serum magnesium concentrations were measured using an enzymatic method. Multivariable linear regression models were used to estimate means of fasting insulin, fasting plasma glucose, homeostatic model assessment of insulin resistance (HOMA-IR), homeostatic model assessment of beta-cell function (HOMA-beta), and glycated hemoglobin (HbA1c), with adjustments made for potential confounding variables.Results: Dietary magnesium was inversely associated with HOMA-IR (P-trend = 0.01). Multivariable-adjusted means (95% confidence intervals) of HOMA-IR for the lowest to highest quartiles of dietary magnesium were 0.94 (0.89-0.99), 0.92 (0.88-0.97), 0.88 (0.83-0.92), and 0.86 (0.81-0.90). Serum magnesium concentrations were also inversely associated with HOMA-IR (P-trend = 0.04) and HbA1c (P-trend < 0.01). Multivariable-adjusted means (95% confidence intervals) for the lowest to highest quartiles of serum magnesium were 0.94 (0.90-0.98), 0.87 (0.83-0.91), 0.90 (0.85-0.95), and 0.86 (0.81-0.92) for HOMA-IR and 5.41 (5.36-5.45), 5.33 (5.28-5.37), 5.30 (5.25-5.36), and 5.28 (5.22-5.35) for HbA1c. Excluding subjects with diabetes did not materially change the association between dietary magnesium and HOMA-IR (P-trend < 0.01), while it attenuated the association of serum magnesium with HOMA-IR (P-trend = 0.27) and HbA1c (P-trend = 0.15).Conclusions: The present findings suggest that lower dietary magnesium, but not serum magnesium, is associated with IR in apparently healthy adults. (c) 2018 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.