Effect of chronic social defeat stress on behaviors and dopamine receptor in adult mice
Effect of chronic social defeat stress on behaviors and dopamine receptor in adult mice
复制标题
慢性社交失败压力对成年小鼠行为和多巴胺受体的影响。
DOI：
10.1016/j.pnpbp.2015.12.002
复制
发表时间：
2016-04-03
影响因子：
5.6
通讯作者：
Lv, Lu-Xian
中科院分区：
文献类型：
--
作者：
Huang, Guang-Biao;Zhao, Tong;Lv, Lu-Xian
欺凌的受害者经常出现抑郁、自卑、高度焦虑和创伤后应激障碍症状。社会失败模型已被广泛接受，用于研究与欺凌相关的实验动物行为变化；然而，尚未充分研究易感和不易感个体的影响差异。本研究调查了社交失败压力对成年小鼠行为以及大脑中多巴胺受体 D1 和 D2 表达的影响。经过10天的社交失败压力后，成年小鼠被分为易感组和不易感组。进行了行为测试，并通过蛋白质印迹法评估了大脑中的蛋白质水平。结果表明，所有小鼠的运动能力下降，焦虑行为增加。然而，仅在易感小鼠中观察到社交互动减少和记忆力受损。仅在易感小鼠的前额皮质和杏仁核中观察到 D1 表达显着降低。在任何研究区域中，对照小鼠和失败小鼠之间的 D2 表达均未显示出显着差异。这些数据表明，易感小鼠因社交失败压力引起的抑郁样行为和认知障碍可能与多巴胺受体D1的变化有关。 (C) 2015 Elsevier Inc. 保留所有权利。
Victims of bullying often undergo depression, low self-esteem, high anxiety and post-traumatic stress disorder symptoms. The social defeat model has become widely accepted for studying experimental animal behavior changes associated with bullying; however, differences in the effects in susceptible and unsusceptible individuals have not been well studied. The present study investigated the effects of social defeat stress on behavior and the expression of dopamine receptors D1 and D2 in the brains of adult mice. Adult mice were divided into susceptible and unsusceptible groups after 10 days of social defeat stress. Behavioral tests were conducted, and protein levels in the brains were assessed by Western blotting. The results indicate that all mice undergo decreased locomotion and increased anxiety behavior. However, decreased social interaction and impaired memory performance were only observed in susceptible mice. A significantly decreased expression of D1 was observed in the prefrontal cortex and amygdala of susceptible mice only. No significant differences in D2 expression were shown between control and defeated mice in any area studied. These data indicate that depression-like behavior and cognition impairment caused by social defeat stress in susceptible mice may be related to changes in the dopamine receptor D1. (C) 2015 Elsevier Inc. All rights reserved.