Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols
Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols
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通过 N-杂环卡宾催化双酚去对称化获得 P-立体次膦酸盐
DOI：
10.1021/jacs.6b04624
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发表时间：
2016-06-22
影响因子：
15
通讯作者：
Chi, Yonggui Robin
中科院分区：
文献类型：
--
作者：
Huang, Zhijian;Huang, Xuan;Chi, Yonggui Robin
本发明公开了一种卡宾催化的具有远程P-立体生成中心的前手性双酚化合物的去对称反应。催化反应可以在克尺度上进行，使用1mol%N-杂环卡宾(NHC)催化剂，可以有效地获得富含对映体的P-立体生成膦酸酯。用我们的方法制备的手性膦酸酯可广泛应用于不对称有机催化剂和配体。
A carbene-catalyzed desymmetrization of prochiral bisphenol compounds bearing remote P-stereo genic centers is disclosed. The catalytic reactions can be performed on gram scales with 1 mol % N-heterocyclic carbene (NHC) catalyst, providing efficient access to enantiomerically enriched P-stereogenic phosphinates. The chiral phosphinates prepared with our method can find widespread applications as asymmetric organic catalysts and ligands.