Nickel-Catalyzed Difunctionalization of Unactivated Alkenes Initiated by Unstabilized Enolates
Nickel-Catalyzed Difunctionalization of Unactivated Alkenes Initiated by Unstabilized Enolates
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DOI：
10.1021/jacs.9b09245
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发表时间：
2019-10-16
影响因子：
15
通讯作者：
Newhouse, Timothy R.
中科院分区：
文献类型：
--
作者：
Huang, David;Olivieri, Diego;Newhouse, Timothy R.
这份报告证明了镍催化的未活化的烯烃的双官能化的可能性发起的不稳定的烯醇化亲核试剂。该方法容许多种亲电试剂，包括芳基、杂芳基、烯基和氨基亲电试剂。缺电子膦配体和四丁基铵盐添加剂对于促进有效的邻位双官能化至关重要。
This report demonstrates the possibility of a nickel-catalyzed difunctionalization of unactivated alkenes initiated by an unstabilized enolate nucleophile. The process tolerates a diverse range of electrophiles, including aryl, heteroaryl, alkenyl, and amino electrophiles. An electron-deficient phosphine ligand and a tetrabutylammonium salt additive were crucial for promoting efficient vicinal difunctionalization.